ArticleMolecular and cellular biology1999
RNA polymerase II transcription suppresses nucleosomal modulation of UV-induced (6-4) photoproduct and cyclobutane pyrimidine dimer repair in yeast.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Transcription of ncRNAs promotes repair of UV induced DNA lesions in Saccharomyces cerevisiae subtelomeres.PLoS genetics · 2022Article
- Distinct roles for RSC and SWI/SNF chromatin remodelers in genomic excision repair.Genome research · 2021Article
- Asymmetric repair of UV damage in nucleosomes imposes a DNA strand polarity on somatic mutations in skin cancer.Genome research · 2020Article
- Recurrent Noncoding Mutations in Skin Cancers: UV Damage Susceptibility or Repair Inhibition as Primary Driver?BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Nucleosome positions establish an extended mutation signature in melanoma.PLoS genetics · 2018Article
- Single-nucleotide resolution dynamic repair maps of UV damage inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu-Sir4 interaction.Nucleic acids research · 2017Article
- Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription.Transcription · 2016Article
- Structure of transcribed chromatin is a sensor of DNA damage.Science advances · 2015Article
- ATP-dependent chromatin remodeling in the DNA-damage response.Epigenetics & chromatin · 2012Article
- Nucleoid-associated proteins affect mutation dynamics in E. coli in a growth phase-specific manner.PLoS computational biology · 2012Article
- Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major.Journal of nucleic acids · 2010Article
- Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER.Nucleic acids research · 2010Article
- Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites.Science (New York, N.Y.) · 2009Article
- Roles for Gcn5p and Ada2p in transcription and nucleotide excision repair at the Saccharomyces cerevisiae MET16 gene.Nucleic acids research · 2006Article
- Repair-independent chromatin assembly onto active ribosomal genes in yeast after UV irradiation.Molecular and cellular biology · 2005Article
- UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locus.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Kinetochores prevent repair of UV damage in Saccharomyces cerevisiae centromeres.Molecular and cellular biology · 2004Article
- Dissecting transcription-coupled and global genomic repair in the chromatin of yeast GAL1-10 genes.The Journal of biological chemistry · 2004Article
- Cbf1p modulates chromatin structure, transcription and repair at the Saccharomyces cerevisiae MET16 locus.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleotide excision repair (NER) pathway is able to remove a wide variety of structurally unrelated lesions from DNA. NER operates throughout the genome, but the efficiencies of lesion removal are not the same for different genomic regions. Even within a single gene or DNA strand repair rates vary, and this intragenic heterogeneity is of considerable interest with respect to the mutagenic potential of carcinogens. In this study, we have analyzed the removal of the two major types of genotoxic DNA adducts induced by UV light, i.e., the pyrimidine (6-4)-pyrimidone photoproduct (6-4PP) and the cyclobutane pyrimidine dimer (CPD), from the Saccharomyces cerevisiae URA3 gene at nucleotide resolution. In contrast to the fast and uniform removal of CPDs from the transcribed strand, removal of lesions from the nontranscribed strand is generally less efficient and is modulated by the chromatin environment of the damage. Removal of 6-4PPs from nontranscribed sequences is also profoundly influenced by positioned nucleosomes, but this type of lesion is repaired at a much higher rate. Still, the transcribed strand is repaired preferentially, indicating that, as in the removal of CPDs, transcription-coupled repair predominates in the removal of 6-4PPs from transcribed DNA. The hypothesis that transcription machinery operates as the rate-determining damage recognition entity in transcription-coupled repair is supported by the observation that this pathway removes both types of UV photoproducts at equal rates without being profoundly influenced by the sequence or chromatin context.
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