ArticleMolecular and cellular biology1999
Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Chromatin protein PC4 is downregulated in breast cancer to promote disease progression: Implications of miR-29a.Oncotarget · 2019Article
- The biological characteristics of transcription factors AP-2α and AP-2γ and their importance in various types of cancers.Bioscience reports · 2019Review
- Interaction of positive coactivator 4 with histone 3.3 protein is essential for transcriptional activation of the luteinizing hormone receptor gene.Biochimica et biophysica acta. Gene regulatory mechanisms · 2018Article
- MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.Oncogene · 2016Article
- The Sub1 nuclear protein protects DNA from oxidative damage.Molecular and cellular biochemistry · 2016Article
- Inhibition of human positive cofactor 4 radiosensitizes human esophageal squmaous cell carcinoma cells by suppressing XLF-mediated nonhomologous end joining.Cell death & disease · 2014Article
- Human positive coactivator 4 is a potential novel therapeutic target in non-small cell lung cancer.Cancer gene therapy · 2012Article
- Spaceflight alters the gene expression profile of cervical cancer cells.Chinese journal of cancer · 2011Article
- Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription.The Journal of biological chemistry · 2011Article
- Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes.BMC genomics · 2010Article
- The combined immunodetection of AP-2alpha and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors.Breast cancer research : BCR · 2008Article
- Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications.Molecular and cellular biology · 2007Article
- p53 regulates its own activator: transcriptional co-activator PC4, a new p53-responsive gene.The Biochemical journal · 2007Article
- Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation.Molecular and cellular biology · 2006Article
- The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage.Molecular and cellular biology · 2004Article
- An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- General transcriptional coactivator PC4 activates p53 function.Molecular and cellular biology · 2004Article
- Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region.The Biochemical journal · 2004Article
- Transcriptional activation by AP-2alpha is modulated by the oncogene DEK.Nucleic acids research · 2003Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
ras oncogene-transformed PA-1 human teratocarcinoma cells have abundant AP-2 mRNA but, paradoxically, little AP-2 transcriptional activity. We have previously shown that overexpression of AP-2 in nontumorigenic variants of PA-1 cells results in inhibition of AP-2 activity and induction of tumorigenicity similar to that caused by ras transformation of PA-1 cells. Evidence indicated the existence of a novel mechanism of inhibition of AP-2 activity involving sequestering of transcriptional coactivators. In this study, we found that PC4 is a positive coactivator of AP-2 and can restore AP-2 activity in ras-transformed PA-1 cells. Relative to vector-transfected ras cell lines, ras cell lines stably transfected with and expressing the PC4 cDNA have a diminished growth rate and exhibit a loss of anchorage-independent growth, and they are unable to induce the formation of tumors in nude mice. These data suggest that a transcriptional coactivator, like a tumor suppressor, can have a growth-suppressive effect on cells. Our experiments are the first to show that ras oncogenes and oncogenic transcription factors can induce transformation through effects on the transcription machinery rather than through specific programs of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.