ArticleMolecular and cellular biology1999
The two Drosophila telomeric transposable elements have very different patterns of transcription.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
- Exploring the Relationship of Transposable Elements and Ageing: Causes and Consequences.Genome biology and evolution · 2025Review
- Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species.Mobile DNA · 2023Article
- Nuclear Ccr4-Not mediates the degradation of telomeric and transposon transcripts at chromatin in the Drosophila germline.Nucleic acids research · 2020Article
- Additional ORFs in Plant LTR-Retrotransposons.Frontiers in plant science · 2020Review
- Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline.Epigenetics & chromatin · 2018Article
- Article
- Natural variation of piRNA expression affects immunity to transposable elements.PLoS genetics · 2017Article
- Antisense Transcription of Retrotransposons in Drosophila: An Origin of Endogenous Small Interfering RNA Precursors.Genetics · 2016Article
- Insertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome Maintenance.Frontiers in genetics · 2015Review
- Article
- If the cap fits, wear it: an overview of telomeric structures over evolution.Cellular and molecular life sciences : CMLS · 2014Review
- Retrotransposons at Drosophila telomeres: host domestication of a selfish element for the maintenance of genome integrity.Biochimica et biophysica acta · 2012Review
- Retrotransposons that maintain chromosome ends.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Transcriptional analysis of the HeT-A retrotransposon in mutant and wild type stocks reveals high sequence variability at Drosophila telomeres and other unusual features.BMC genomics · 2011Article
- Adapting to life at the end of the line: How Drosophila telomeric retrotransposons cope with their job.Mobile genetic elements · 2011Article
- Differential maintenance of DNA sequences in telomeric and centromeric heterochromatin.Genetics · 2011Article
- Evolution of diverse mechanisms for protecting chromosome ends by Drosophila TART telomere retrotransposons.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- rasiRNA pathway controls antisense expression of Drosophila telomeric retrotransposons in the nucleus.Nucleic acids research · 2009Article
- Regulation of telomere length in Drosophila.Cytogenetic and genome research · 2008Review
- Molecular characterization of a retrotransposon in the Rhynchosciara americana genome and its association with telomere.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The transposable elements HeT-A and TART constitute the telomeres of Drosophila chromosomes. Both are non-long terminal repeat (LTR) retrotransposons, sharing the remarkable property of transposing only to chromosome ends. In addition, strong sequence similarity of their gag proteins indicates that these coding regions share a common ancestor. These findings led to the assumption that HeT-A and TART are closely related. However, we now find that these elements produce quite different sets of transcripts. HeT-A produces only sense-strand transcripts of the full-length element, whereas TART produces both sense and antisense full-length RNAs, with antisense transcripts in more than 10-fold excess over sense RNA. In addition, features of TART sequence organization resemble those of a subclass of non-LTR elements characterized by unequal terminal repeats. Thus, the ancestral gag sequence appears to have become incorporated in two different types of elements, possibly with different functions in the telomere. HeT-A transcripts are found in both nuclear and cytoplasmic cell fractions, consistent with roles as both mRNA and transposition template. In contrast, both sense and antisense TART transcripts are almost entirely concentrated in nuclear fractions. Also, TART open reading frame 2 probes detect a cytoplasmic mRNA for reverse transcriptase (RT), with no similarity to TART sequence 5' or 3' of the RT coding region. This RNA could be a processed TART transcript or the product of a "free-standing" RT gene. Either origin would be novel. The distinctive transcription patterns of both HeT-A and TART are conserved in Drosophila yakuba, despite significant sequence divergence. The conservation argues that these sets of transcripts are important to the function(s) of HeT-A and TART.
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