ArticleMolecular and cellular biology1999
Direct regulation of mitochondrial RNA synthesis by thyroid hormone.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 152 citations in OpenAlex.
- Multifunctional Janus Membrane Promotes Neurovascular Network Regeneration for Diabetic Wound Healing.Advanced healthcare materials · 2026Article
- Mitochondrial dysfunction in the regulation of aging and aging-related diseases.Cell communication and signaling : CCS · 2025Review
- An updated compendium and reevaluation of the evidence for nuclear transcription factor occupancy over the mitochondrial genome.PloS one · 2025Article
- Mitochondrial signal transduction.Cell metabolism · 2022Review
- Article
- Thyroid hormones and the potential for regulating glucose metabolism in cardiomyocytes during insulin resistance and T2DM.Physiological reports · 2021Review
- Mechanisms of mammalian mitochondrial transcription.Protein science : a publication of the Protein Society · 2019Review
- Global DNA methylation synergistically regulates the nuclear and mitochondrial genomes in glioblastoma cells.Nucleic acids research · 2018Article
- Mitochondrial-epigenetic crosstalk in environmental toxicology.Toxicology · 2017Review
- Article
- Thyroid Hormone Mediated Modulation of Energy Expenditure.International journal of molecular sciences · 2015Review
- Mito-nuclear co-evolution: the positive and negative sides of functional ancient mutations.Frontiers in genetics · 2014Review
- Evidence for site-specific occupancy of the mitochondrial genome by nuclear transcription factors.PloS one · 2014Article
- Article
- Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.Molecular metabolism · 2013Article
- Modeling RNA polymerase interaction in mitochondria of chordates.Biology direct · 2012Article
- Glucocorticoid and estrogen receptors are reduced in mitochondria of lung epithelial cells in asthma.PloS one · 2012Article
- 3,5-diiodo-L-thyronine increases FoF1-ATP synthase activity and cardiolipin level in liver mitochondria of hypothyroid rats.Journal of bioenergetics and biomembranes · 2011Article
- Mitochondrial DNA transcription regulation and nucleoid organization.Journal of inherited metabolic disease · 2011Review
- Moult cycle specific differential gene expression profiling of the crab Portunus pelagicus.BMC genomics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analyzed the influence of in vivo treatment and in vitro addition of thyroid hormone on in organello mitochondrial DNA (mtDNA) transcription and, in parallel, on the in organello footprinting patterns at the mtDNA regions involved in the regulation of transcription. We found that thyroid hormone modulates mitochondrial RNA levels and the mRNA/rRNA ratio by influencing the transcriptional rate. In addition, we found conspicuous differences between the mtDNA dimethyl sulfate footprinting patterns of mitochondria derived from euthyroid and hypothyroid rats at the transcription initiation sites but not at the mitochondrial transcription termination factor (mTERF) binding region. Furthermore, direct addition of thyroid hormone to the incubation medium of mitochondria isolated from hypothyroid rats restored the mRNA/rRNA ratio found in euthyroid rats as well as the mtDNA footprinting patterns at the transcription initiation area. Therefore, we conclude that the regulatory effect of thyroid hormone on mitochondrial transcription is partially exerted by a direct influence of the hormone on the mitochondrial transcription machinery. Particularly, the influence on the mRNA/rRNA ratio is achieved by selective modulation of the alternative H-strand transcription initiation sites and does not require the previous activation of nuclear genes. These results provide the first functional demonstration that regulatory signals, such as thyroid hormone, that modify the expression of nuclear genes can also act as primary signals for the transcriptional apparatus of mitochondria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.