ArticleMolecular and cellular biology1999
The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Biphasic control of the B cell transcriptome by mTORC1 and GSK3.Cell reports · 2025Article
- Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia.Blood neoplasia · 2025Article
- Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease.Advances in experimental medicine and biology · 2024Review
- Regulation of B cell receptor signalling by Epstein-Barr virus nuclear antigens.The Biochemical journal · 2022Article
- FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors.Frontiers in immunology · 2022Article
- Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation.Nature communications · 2021Article
- EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex.Scientific reports · 2021Article
- EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.PLoS pathogens · 2017Article
- The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.Immunological reviews · 2014Review
- Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma.Leukemia · 2013Article
- Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The 'zinc knuckle' motif of Early B cell Factor is required for transcriptional activation of B cell-specific genes.Molecular immunology · 2008Article
- Early B cell factor: Regulator of B lineage specification and commitment.Seminars in immunology · 2008Review
- Article
- Evi3, a zinc-finger protein related to EBFAZ, regulates EBF activity in B-cell leukemia.Oncogene · 2005Article
- Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression.BMC cancer · 2004Article
- Bystander gene activation by a locus control region.The EMBO journal · 2004Article
- Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage.The EMBO journal · 2003Article
- Inhibition of p300/CBP by early B-cell factor.Molecular and cellular biology · 2003Article
- The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers.Molecular and cellular biology · 2002Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early B-cell factor (EBF) is a transcription factor suggested as essential for early B-lymphocyte development by findings in mice where the coding gene has been inactivated by homologous disruption. This makes the identification of genetic targets for this transcription factor pertinent for the understanding of early B-cell development. The lack of B29 transcripts, coding for the beta subunit of the B-cell receptor complex, in pro-B cells from EBF-deficient mice suggested that B29 might be a genetic target for EBF. We here present data suggesting that EBF interacts with three independent sites within the mouse B29 promoter. Furthermore, ectopic expression of EBF in HeLa cells activated a B29 promoter-controlled reporter construct 13-fold and induced a low level of expression from the endogenous B29 gene. Finally, mutations in the EBF binding sites diminished B29 promoter activity in pre-B cells while the same mutations did not have as striking an effect on the promoter function in B-cell lines of later differentiation stages. These data suggest that the B29 gene is a genetic target for EBF in early B-cell development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.