ArticleMolecular and cellular biology1999
Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
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- A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae.Nucleic acids research · 2021Article
- Review
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- The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation.Molecular cell · 2017Article
- Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity.RNA (New York, N.Y.) · 2016Article
- Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance.Antimicrobial agents and chemotherapy · 2015Article
- Specialized ribosomes: a new frontier in gene regulation and organismal biology.Nature reviews. Molecular cell biology · 2012Review
- A rapid, inexpensive yeast-based dual-fluorescence assay of programmed--1 ribosomal frameshifting for high-throughput screening.Nucleic acids research · 2011Article
- Translational errors: from yeast to new therapeutic targets.FEMS yeast research · 2010Review
- Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen.Molecular & cellular proteomics : MCP · 2010Article
- Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins.Journal of virology · 2010Article
- Ribosomal protein L3 functions as a 'rocker switch' to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea.Nucleic acids research · 2008Article
- Identification of novel ligands for the RNA pseudoknot that regulate -1 ribosomal frameshifting.Bioorganic & medicinal chemistry · 2008Article
- Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation.RNA (New York, N.Y.) · 2007Article
- Cloning and characterization of the ribosomal protein L3 (RPL3) gene family from Triticum aestivum.Molecular genetics and genomics : MGG · 2007Article
- Ribosomal protein L3: gatekeeper to the A site.Molecular cell · 2007Article
- Functional analysis of Saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis.Nucleic acids research · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Programmed -1 ribosomal frameshifting is utilized by a number of RNA viruses as a means of ensuring the correct ratio of viral structural to enzymatic proteins available for viral particle assembly. Altering frameshifting efficiencies upsets this ratio, interfering with virus propagation. We have previously demonstrated that compounds that alter the kinetics of the peptidyl-transfer reaction affect programmed -1 ribosomal frameshift efficiencies and interfere with viral propagation in yeast. Here, the use of a genetic approach lends further support to the hypothesis that alterations affecting the ribosome's peptidyltransferase activity lead to changes in frameshifting efficiency and virus loss. Mutations in the RPL3 gene, which encodes a ribosomal protein located at the peptidyltransferase center, promote approximately three- to fourfold increases in programmed -1 ribosomal frameshift efficiencies and loss of the M1 killer virus of yeast. The mak8-1 allele of RPL3 contains two adjacent missense mutations which are predicted to structurally alter the Mak8-1p. Furthermore, a second allele that encodes the N-terminal 100 amino acids of L3 (called L3Delta) exerts a trans-dominant effect on programmed -1 ribosomal frameshifting and killer virus maintenance. Taken together, these results support the hypothesis that alterations in the peptidyltransferase center affect programmed -1 ribosomal frameshifting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.