ArticleMolecular and cellular biology1999
DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 85 citations in OpenAlex.
- DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle.Scientific reports · 2023Article
- DNA methylation, through DNMT1, has an essential role in the development of gastrointestinal smooth muscle cells and disease.Cell death & disease · 2018Article
- Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-Scientific reports · 2016Article
- Functional complementation between transcriptional methylation regulation and post-transcriptional microRNA regulation in the human genome.BMC genomics · 2011Article
- An integrative analysis of DNA methylation and RNA-Seq data for human heart, kidney and liver.BMC systems biology · 2011Article
- Dissection of structure and function of the N-terminal domain of mouse DNMT1 using regional frame-shift mutagenesis.PloS one · 2010Article
- Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice.BMC physiology · 2008Article
- RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Identification and characterization of bovine regulator of telomere length elongation helicase gene (RTEL): molecular cloning, expression distribution, splice variants and DNA methylation profile.BMC molecular biology · 2007Article
- Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation.Nucleic acids research · 2007Article
- Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development.Molecular and cellular biology · 2006Article
- Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- DNA methylation may restrict but does not determine differential gene expression at the Sgy/Tead2 locus during mouse development.Molecular and cellular biology · 2004Article
- The study of aberrant methylation in cancer via restriction landmark genomic scanning.Oncogene · 2002Review
- Review
- Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.Oncogene · 2002Article
- Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer.British journal of cancer · 2001Article
- Protein binding protects sites on stable episomes and in the chromosome from de novo methylation.Molecular and cellular biology · 2001Article
- Establishment and maintenance of DNA methylation patterns in mouse Ndn: implications for maintenance of imprinting in target genes of the imprinting center.Molecular and cellular biology · 2001Article
- Chromosomal DNA demethylation specified by protein binding.EMBO reports · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic levels of DNA methylation undergo widespread alterations in early embryonic development. However, changes in embryonic methylation have proven difficult to study at the level of single-copy genes due to the small amount of tissue available for assay. This study provides the first detailed analysis of the methylation state of a tissue-specific gene through early development and differentiation. Using bisulfite sequencing, we mapped the methylation profile of the tissue-specific mouse skeletal alpha-actin promoter at all stages of development, from gametes to postimplantation embryos. We show that the alpha-actin promoter, which is fully methylated in the sperm and essentially unmethylated in the oocyte, undergoes a general demethylation from morula to blastocyst stages, although the blastula is not completely demethylated. Remethylation of the alpha-actin promoter occurs after implantation in a stochastic pattern, with some molecules being extensively methylated and others sparsely methylated. Moreover, we demonstrate that tissue-specific expression of the skeletal alpha-actin gene in the adult mouse does not correlate with the methylation state of the promoter, as we find a similar low level of methylation in both expressing and one of the two nonexpressing tissues tested. However, a subset of CpG sites within the skeletal alpha-actin promoter are preferentially methylated in liver, a nonexpressing tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.