ArticleThe Journal of experimental medicine1998
Genetic control of natural killing and in vivo tumor elimination by the Chok locus.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 42 citations in OpenAlex.
- Genetic dissection of NK cell responses.Frontiers in immunology · 2012Article
- Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1.Biology of reproduction · 2010Article
- Endostatin gene therapy enhances the efficacy of IL-2 in suppressing metastatic renal cell carcinoma in mice.Cancer immunology, immunotherapy : CII · 2010Article
- Ligand dimensions are important in controlling NK-cell responses.European journal of immunology · 2010Article
- A role for NKG2D in NK cell-mediated resistance to poxvirus disease.PLoS pathogens · 2008Article
- The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA.Infection and immunity · 2005Article
- Natural killer cell immune responses.Immunologic research · 2005Review
- Genetic control of innate immune responses against cytomegalovirus: MCMV meets its match.Genes and immunity · 2002Review
- Requirement for membrane lymphotoxin in natural killer cell development.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance.OncoimmunologyArticle
- Enhanced protection of C57 BL/6 vs Balb/c mice to melanoma liver metastasis is mediated by NK cells.OncoimmunologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms underlying target recognition during natural killing are not well understood. One approach to dissect the complexities of natural killer (NK) cell recognition is through exploitation of genetic differences among inbred mouse strains. In this study, we determined that interleukin 2-activated BALB/c-derived NK cells could not lyse Chinese hamster ovary (CHO) cells as efficiently as C57BL/6-derived NK cells, despite equivalent capacity to kill other targets. This strain-determined difference was also exhibited by freshly isolated NK cells, and was determined to be independent of host major histocompatibility haplotype. Furthermore, CHO killing did not correlate with expression of NK1.1 or 2B4 activation molecules. Genetic mapping studies revealed linkage between the locus influencing CHO killing, termed Chok, and loci encoded within the NK gene complex (NKC), suggesting that Chok encodes an NK cell receptor specific for CHO cells. In vivo assays recapitulated the in vitro data, and both studies determined that Chok regulates an NK perforin-dependent cytotoxic process. These results may have implications for the role of NK cells in xenograft rejection. Our genetic analysis suggests Chok is a single locus that affects NK cell-mediated cytotoxicity similar to other NKC loci that also regulate the complex activity of NK cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.