ArticleThe EMBO journal1998
Regionalized metabolic activity establishes boundaries of retinoic acid signalling.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.
- Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration.BMC developmental biology · 2011Pooled it
- Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion.Frontiers in cell and developmental biology · 2023Article
- Enhanced Loss of Retinoic Acid Network Genes inCells · 2022Article
- Retinoic Acid is Required for Normal Morphogenetic Movements During Gastrulation.Frontiers in cell and developmental biology · 2022Article
- Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly.Frontiers in cell and developmental biology · 2022Article
- AOP Key Event Relationship report: Linking decreased retinoic acid levels with disrupted meiosis in developing oocytes.Current research in toxicology · 2022Article
- Retinoic Acid Fluctuation Activates an Uneven, Direction-Dependent Network-Wide Robustness Response in Early Embryogenesis.Frontiers in cell and developmental biology · 2021Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- The Xenopus animal cap transcriptome: building a mucociliary epithelium.Nucleic acids research · 2018Article
- Retinoic acid-induced expression ofDevelopment (Cambridge, England) · 2018Article
- Generating retinoic acid gradients by local degradation during craniofacial development: One cell's cue is another cell's poison.Genesis (New York, N.Y. : 2000) · 2018Review
- A multichannel computer-driven system to raise aquatic embryos under selectable hypoxic conditions.Hypoxia (Auckland, N.Z.) · 2018Article
- xCyp26c Induced by Inhibition of BMP Signaling Is Involved in Anterior-Posterior Neural Patterning of Xenopus laevis.Molecules and cells · 2016Article
- Retinoic acid regulation by CYP26 in vertebrate lens regeneration.Developmental biology · 2014Article
- Dhrs3 protein attenuates retinoic acid signaling and is required for early embryonic patterning.The Journal of biological chemistry · 2013Article
- Retinoic acid synthesis and functions in early embryonic development.Cell & bioscience · 2012Article
- Short chain dehydrogenase/reductase rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development.The Journal of biological chemistry · 2012Article
- Cytochrome P450s in the regulation of cellular retinoic acid metabolism.Annual review of nutrition · 2011Review
- Developmental expression of Xenopus short-chain dehydrogenase/reductase 3.The International journal of developmental biology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The competence of a cell to respond to the signalling molecule retinoic acid (RA) is thought to depend largely on its repertoire of cognate zinc finger nuclear receptors. XCYP26 is an RA hydroxylase that is expressed differentially during early Xenopus development. In Xenopus embryos, XCYP26 can rescue developmental defects induced by application of exogenous RA, suggesting that the enzymatic modifications introduced inhibit RA signalling activities in vivo. Alterations in the expression pattern of a number of different molecular markers for neural development induced upon ectopic expression of XCYP26 reflect a primary function of RA signalling in hindbrain development. Progressive inactivation of RA signalling results in a stepwise anteriorization of the molecular identity of individual rhombomeres. The expression pattern of XCYP26 during gastrulation appears to define areas within the prospective neural plate that develop in response to different concentrations of RA. Taken together, these observations appear to reflect an important regulatory function of XCYP26 for RA signalling; XCYP26-mediated modification of RA modulates its signalling activity and helps to establish boundaries of differentially responsive and non-responsive territories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.