ArticleThe EMBO journal1998
A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 101 citations in OpenAlex.
- Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2.Experimental & molecular medicine · 2024Review
- PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders.Cellular and molecular life sciences : CMLS · 2022Article
- Review
- Ancient friends, revisited: Systematic review and case report of pyoderma gangrenosum-associated autoinflammatory syndromes.Journal of translational autoimmunity · 2020Review
- CD2 Immunobiology.Frontiers in immunology · 2020Review
- Deciphering the BAR code of membrane modulators.Cellular and molecular life sciences : CMLS · 2017Review
- F-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases.Journal of hematology & oncology · 2015Review
- The SAPHO syndrome revisited with an emphasis on spinal manifestations.Skeletal radiology · 2015Review
- Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice.PloS one · 2011Article
- Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review.Current genomics · 2010Article
- Longest form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients.Digestive diseases and sciences · 2010Article
- Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.The Journal of biological chemistry · 2009Article
- Pyrin Modulates the Intracellular Distribution of PSTPIP1.PloS one · 2009Article
- PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis.Developmental biology · 2008Article
- Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.The EMBO journal · 2002Article
- CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A feline CD2 homologue interacts with human red blood cells.Immunology · 2002Article
- A subtle role for CD2 in T cell antigen recognition.The Journal of experimental medicine · 1999Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A human CD2 cytoplasmic tail-binding protein, termed CD2BP1, was identified by an interaction trap cloning method. Expression of CD2BP1 is restricted to hematopoietic tissue, being prominent in T and natural killer (NK) cells, with long (CD2BP1L) and short (CD2BP1S) variants arising by alternative RNA splicing. Both CD2BP1 molecules are homologous to Schizosaccharomyces pombe cdc15, and include a helical domain, variable length intervening PEST sequence and C-terminal SH3 domain. Although the CD2BP1 SH3 domain binds directly to the CD2 sequence, KGPPLPRPRV (amino acids 300-309), its association is augmented markedly by the CD2BP1 N-terminal segment. Upon ligand-induced clustering of surface CD2 molecules, CD2BP1 redistributes from a cytosolic to a surface membrane compartment, co-localizing with CD2. In turn, CD2-stimulated adhesion is downregulated by CD2BP1, apparently through coupling of the protein tyrosine phosphatase (PTP)-PEST to CD2. These findings offer the first molecular view into the control processes for T cell adhesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.