ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 121 citations in OpenAlex.
- Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis.Redox biology · 2019Article
- PI3K/Akt and ERK/MAPK Signaling Promote Different Aspects of Neuron Survival and Axonal Regrowth Following Rat Facial Nerve Axotomy.Neurochemical research · 2017Article
- ERK/MAPK and PI3K/AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury.Saudi journal of biological sciences · 2017Article
- TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response.Nature communications · 2017Article
- Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.Neuro-oncology · 2015Article
- NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.Genes & development · 2014Article
- Ras protein activation is a key event in activity-dependent survival of cerebellar granule neurons.The Journal of biological chemistry · 2014Article
- Ephrin-B2 expression in the proprioceptive sensory system.Neuroscience letters · 2013Article
- Human mesenchymal stem cells increase anti-oxidant defences in cells derived from patients with Friedreich's ataxia.Cerebellum (London, England) · 2012Article
- Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner.Molecular and cellular neurosciences · 2012Article
- Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I.Human molecular genetics · 2011Article
- Ras signaling pathways mediate NGF-induced enhancement of excitability of small-diameter capsaicin-sensitive sensory neurons from wildtype but not Nf1+/- mice.Neuroscience letters · 2011Article
- Adenosine kinase regulation of cardiomyocyte hypertrophy.American journal of physiology. Heart and circulatory physiology · 2011Article
- Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected].Experimental & molecular medicine · 2010Article
- Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/⁻ mice.Journal of neurophysiology · 2010Article
- On Trk--the TrkB signal transduction pathway is an increasingly important target in cancer biology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Review
- Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5.Cell death and differentiation · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nerve growth factor (NGF) is a required differentiation and survival factor for sympathetic and a majority of neural crest-derived sensory neurons in the developing vertebrate peripheral nervous system. Although much is known about the function of NGF, the intracellular signaling cascade that it uses continues to be a subject of intense study. p21 ras signaling is considered necessary for sensory neuron survival. How additional intermediates downstream or in parallel may function has not been fully understood yet. Two intracellular signaling cascades, extra cellular regulated kinase (erk) and phosphatidylinositol-3 (PI 3) kinase, transduce NGF signaling in the pheochromocytoma cell line PC12. To elucidate the role these cascades play in survival and differentiation, we used a combination of recombinant adenoviruses and chemical inhibitors to perturb these pathways in sensory neurons from wild-type mice and mice deficient for neurofibromin in which the survival and differentiation pathway is constitutively active. We demonstrate that ras activity is both necessary and sufficient for the survival of embryonic sensory neurons. Downstream of ras, however, the erk cascade is neither required nor sufficient for neuron survival or overall differentiation. Instead, the activity of PI 3 kinase is necessary for the survival of the wild-type and neurofibromin-deficient neurons. Therefore, we conclude that in sensory neurons, NGF acts via a signaling pathway, which includes both ras and PI 3 kinase.
Indexed as
Identifiers
9852579PMC6793354W2108885540What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.