ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 76 citations in OpenAlex.
- Spinal neuron-glial crosstalk and ion channel dysregulation in diabetic neuropathic pain.Frontiers in immunology · 2025Review
- Kv2 channels contribute to neuronal activity within the vagal afferent-nTS reflex arc.American journal of physiology. Cell physiology · 2024Article
- The Potassium Channel Kv1.5 Expression Alters During Experimental Autoimmune Encephalomyelitis.Neurochemical research · 2019Article
- Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance.Physiological reviews · 2017Review
- Inhibitory effects of cholinesterase inhibitor donepezil on the Kv1.5 potassium channel.Scientific reports · 2017Article
- Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis.American journal of physiology. Cell physiology · 2016Article
- Developmental expression of Kv1 voltage-gated potassium channels in the avian hypothalamus.Neuroscience letters · 2016Article
- Voltage-dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells.Glia · 2015Article
- Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states.Frontiers in cellular neuroscience · 2015Article
- CNS Schwann cells display oligodendrocyte precursor-like potassium channel activation and antigenic expression in vitro.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.Frontiers in cellular neuroscience · 2013Article
- Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport.Clinical and experimental nephrology · 2012Review
- Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons.American journal of physiology. Cell physiology · 2009Article
- Muscarinic acetylcholine receptor subtype expression in avian vestibular hair cells, nerve terminals and ganglion cells.Neuroscience · 2007Article
- Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells.Molecular biology of the cell · 2006Article
- 4-aminopyridine decreases progesterone production by porcine granulosa cells.Reproductive biology and endocrinology : RB&E · 2003Article
- Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon.The EMBO journal · 2000Article
- Modulation of Kv1.5 currents by Src tyrosine phosphorylation: potential role in the differentiation of astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins.The Journal of experimental medicine · 2000Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schwann cells (SCs) are responsible for myelination of nerve fibers in the peripheral nervous system. Voltage-dependent K+ currents, including inactivating A-type (KA), delayed-rectifier (KD), and inward-rectifier (KIR) K+ channels, constitute the main conductances found in SCs. Physiological studies have shown that KD channels may play an important role in SC proliferation and that they are downregulated in the soma as proliferation ceases and myelination proceeds. Recent studies have begun to address the molecular identity of K+ channels in SCs. Here, we show that a large repertoire of K+ channel alpha subunits of the Shaker (Kv1.1, Kv1.2, Kv1.4, and Kv1.5), Shab (Kv2.1), and Shaw (Kv3.1b and Kv3.2) families is expressed in mouse SCs and sciatic nerve. We characterized heteromultimeric channel complexes that consist of either Kv1.5 and Kv1.2 or Kv1.5 and Kv1.4. In postnatal day 4 (P4) sciatic nerve, most of the Kv1.2 channel subunits are involved in heteromultimeric association with Kv1.5. Despite the presence of Kv1. 1 and Kv1.2 alpha subunits, the K+ currents were unaffected by dendrotoxin I (DTX), suggesting that DTX-sensitive channel complexes do not account substantially for SC KD currents. SC proliferation was found to be potently blocked by quinidine or 4-aminopyridine but not by DTX. Consistent with previous physiological studies, our data show that there is a marked downregulation of all KD channel alpha subunits from P1-P4 to P40 in the sciatic nerve. Our results suggest that KD currents are accounted for by a complex combinatorial activity of distinct K+ channel complexes and confirm that KD channels are involved in SC proliferation.
Indexed as
Identifiers
9852577PMC6793353W2107503430What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.