ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Mammalian nicotinic receptors with alpha7 subunits that slowly desensitize and rapidly recover from alpha-bungarotoxin blockade.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The trial behind it
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Who cites it
31 citing papers in PubMed, 107 citations in OpenAlex.
- Functional expression and properties of the tick α6 homomeric nicotinic acetylcholine receptor inCurrent research in parasitology & vector-borne diseases · 2025Article
- Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions.Pharmacological research · 2023Review
- Recording plasticity in neuronal activity in the rodent intrinsic cardiac nervous system using calcium imaging techniques.Frontiers in synaptic neuroscience · 2023Article
- Loop Diuretics Inhibit Ischemia-Induced Intracellular CaFrontiers in pharmacology · 2021Article
- Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse.Frontiers in neuroanatomy · 2019Article
- Cholinergic modulation of the immune system presents new approaches for treating inflammation.Pharmacology & therapeutics · 2017Review
- Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain.Trends in pharmacological sciences · 2016Review
- σ-1 Receptor Inhibition of ASIC1a Channels is Dependent on a Pertussis Toxin-Sensitive G-Protein and an AKAP150/Calcineurin Complex.Neurochemical research · 2015Article
- Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status.CNS drugs · 2014Review
- Non-specific inhibition of ischemia- and acidosis-induced intracellular calcium elevations and membrane currents by α-phenyl-N-tert-butylnitrone, butylated hydroxytoluene and trolox.International journal of molecular sciences · 2014Article
- Cell-surface translational dynamics of nicotinic acetylcholine receptors.Frontiers in synaptic neuroscience · 2014Review
- Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats.BMC pharmacology & toxicology · 2013Article
- In vitro evaluation of guanidine analogs as sigma receptor ligands for potential anti-stroke therapeutics.The Journal of pharmacology and experimental therapeutics · 2013Article
- Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.British journal of pharmacology · 2012Article
- Phorbol 12-myristate 13-acetate potentiation of N-methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha.The Journal of pharmacology and experimental therapeutics · 2009Article
- Rat neuronal nicotinic acetylcholine receptors containing alpha7 subunit: pharmacological properties of ligand binding and function.Acta pharmacologica Sinica · 2009Article
- The road to discovery of neuronal nicotinic cholinergic receptor subtypes.Handbook of experimental pharmacology · 2009Review
- Action potential-independent and nicotinic receptor-mediated concerted release of multiple quanta at hippocampal CA3-mossy fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- A null mutation for the alpha3 nicotinic acetylcholine (ACh) receptor gene abolishes fast synaptic activity in sympathetic ganglia and reveals that ACh output from developing preganglionic terminals is regulated in an activity-dependent retrograde manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
One of the most abundant nicotinic receptors in the nervous system is a species that contains the alpha7 gene product, rapidly desensitizes, and binds alpha-bungarotoxin with great affinity. The receptor has a high relative permeability to calcium and performs a variety of functions including presynaptic modulation of transmitter release and postsynaptic generation of synaptic currents. Fast excitatory transmission in mammalian intracardiac ganglia is mediated primarily by nicotinic receptors, and although intracardiac ganglion neurons express the alpha7 gene, no toxin-sensitive response has been detected previously in them. We report here that whole-cell patch-clamp recordings from freshly dissociated intracardiac ganglion neurons reveal a nicotinic response that desensitizes slowly and is blocked by alpha-bungarotoxin in a rapidly reversible manner. The only rat gene previously thought capable of forming such receptors was alpha9, but no evidence suggests that the alpha9 gene is expressed in neurons. We find that reverse transcription (RT)-PCR detects alpha7 but not alpha9 mRNA in the ganglia. In addition, the pharmacology of the nicotinic response is typical of alpha7-containing receptors but differs in several respects from that expected for alpha9. Binding experiments with immunotethered receptors identifies a ganglionic species that contains the alpha7 gene product. Moreover, intracellular perfusion of the cells with an anti-alpha7 monoclonal antibody specifically reduces the amplitude of the toxin-sensitive response. The results indicate that alpha7-containing receptors are responsible for the slowly desensitizing, toxin-reversible response and suggest that the receptors are modified in cell-specific ways to influence their functional properties.
Indexed as
Identifiers
9852571PMC6793363W2130282769What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.