ArticleThe Journal of physiology1999
Identification of rhythmically active cells in guinea-pig stomach.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 3 of them syntheses that pooled it.
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Who cites it
133 citing papers in PubMed, 3 syntheses or guidelines pooled it, 307 citations in OpenAlex.
- Electrogastrography in Adult Gastroparesis: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2025Pooled it
- ELECTROGASTROGRAPHY IN PEDIATRIC GASTROPARESIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.Arquivos de gastroenterologia · 2025Pooled it
- A bibliometric analysis of diabetic gastroparesis from 1979 to 2024.Frontiers in medicine · 2024Pooled it
- Methods and Techniques for Closed-Loop Gastrointestinal Pacing.Neurogastroenterology and motility · 2026Article
- Changes in interstitial cells of Cajal calcium activity in a diabetic mouse model of delayed gastric emptying.The Journal of physiology · 2026Article
- Article
- Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility.Neurogastroenterology and motility · 2025Review
- Pharmacologic treatments for gastroparesis.Pharmacological reviews · 2025Review
- Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- CaPhysiological reviews · 2024Review
- Mfge8 is expressed by pericytes in gastric antrum submucosa from patients with obesity.American journal of physiology. Cell physiology · 2023Article
- An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle.The Journal of physiology · 2023Article
- In Silico, In Vitro, and Ex Vivo Biological Activity of Some Novel Mebeverine Precursors.Biomedicines · 2023Article
- Analysis of Regional Variations of the Interstitial Cells of Cajal in the Murine Distal Stomach Informed by Confocal Imaging and Machine Learning Methods.Cellular and molecular bioengineering · 2022Article
- Gastroparesis.Gastroenterology · 2022Review
- Role of gut microbiota-derived signals in the regulation of gastrointestinal motility.Frontiers in medicine · 2022Review
- Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease.Cellular and molecular gastroenterology and hepatology · 2022Review
- CaCell calcium · 2021Article
- Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice.Communications biology · 2021Article
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. When intracellular recordings were made from the antral region of guinea-pig stomach, cells with different patterns of electrical activity were detected. 2. One group of cells, slow-wave cells, generated slow waves which consisted of initial and secondary components. When filled with either Lucifer Yellow or neurobiotin, the cells identified as smooth muscle cells lying in the circular muscle layer. 3. A second group of cells, driving cells, generated large, rapidly rising, potential changes, driving potentials. They had small cell bodies with several processes. With neurobiotin, a network of cells was visualized that resembled c-kit positive interstitial cells of the myenteric region. 4. A third group of cells generated sequences of potential changes which resembled driving potentials but had smaller amplitudes and slow rates of rise. These cells resembled smooth muscle cells lying in the longitudinal muscle layer. 5. When simultaneous recordings were made from the driving and slow-wave cells, driving potentials and slow waves occurred synchronously. Current injections indicated that both cell types were part of a common electrical syncytium. 6. The initial component of slow waves persisted in low concentrations of caffeine, but the secondary component was abolished; higher concentrations shortened the duration of the residual initial component. Driving potentials continued in the presence of low concentrations of caffeine; moderate concentrations of caffeine shortened their duration. 7. Hence three different types of cells were distinguished on the basis of their electrical activity, their responses to caffeine and their structure. These were smooth muscle cells, lying in the longitudinal and circular layers, and interstitial cells in the myenteric region. The observations suggest that interstitial cells initiate slow waves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.