ArticleThe Journal of physiology1999
Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 179 citations in OpenAlex.
- ABCC9/SUR2 has a Complex Expression Pattern in Human Brain Gliovascular Unit Cells, Including Astrocytes.Journal of molecular neuroscience : MN · 2026Article
- Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity.Neuron · 2025Article
- A New Potassium Channel on the Endoplasmic Reticulum Membrane in a Rat Brain: Electropharmacology and Molecular Evidence.Basic and clinical neuroscience · 2025Article
- A Reduction in the Readily Releasable Vesicle Pool Impairs GABAergic Inhibition in the Hippocampus after Blood-Brain Barrier Dysfunction.International journal of molecular sciences · 2024Article
- Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome.Brain : a journal of neurology · 2024Article
- Extended range proteomic analysis of blood plasma from schizophrenia patients.Frontiers in molecular biosciences · 2024Article
- Glycolysis regulates neuronal excitability via lactate receptor, HCA1R.Brain : a journal of neurology · 2023Article
- KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer's disease-related pathology.JCI insight · 2023Article
- Mild hypoxia-induced structural and functional changes of the hippocampal network.Frontiers in cellular neuroscience · 2023Article
- Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice.Molecular neurobiology · 2022Article
- Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity.eLife · 2021Article
- The surprising complexity of KATP channel biology and of genetic diseases.The Journal of clinical investigation · 2020Article
- Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach InvolvingFrontiers in neurology · 2020Review
- Functional characterization of ABCC9 variants identified in sudden unexpected natural death.Forensic science international · 2019Article
- Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency.Science translational medicine · 2019Article
- Blockade of the KMolecular psychiatry · 2018Article
- Modulation of Excitability of Stellate Neurons in the Ventral Cochlear Nucleus of Mice by ATP-Sensitive Potassium Channels.The Journal of membrane biology · 2018Article
- BAD and KeLife · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Electrical Control in Neurons by the Ketogenic Diet.Frontiers in cellular neuroscience · 2018Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The distribution of ATP-sensitive K+ channels (KATP channels) was investigated in four cell types in hippocampal slices prepared from 10- to 13-day-old rats: CA1 pyramidal cells, interneurones of stratum radiatum in CA1, complex glial cells of the same area and granule cells of the dentate gyrus. The neuronal cell types were identified visually and characterized by the shapes and patterns of their action potentials and by neurobiotin labelling. 2. The patch-clamp technique was used to study the sensitivity of whole-cell currents to diazoxide (0.3 mM), a KATP channel opener, and to tolbutamide (0.5 mM) or glibenclamide (20 microM), two KATP channel inhibitors. The fraction of cells in which whole-cell currents were activated by diazoxide and inhibited by tolbutamide was 26% of pyramidal cells, 89 % of interneurones, 100% of glial cells and 89% of granule cells. The reversal potential of the diazoxide-induced current was at the K+ equilibrium potential and a similar current activated spontaneously when cells were dialysed with an ATP-free pipette solution. 3. Using the single-cell RT-PCR method, the presence of mRNA encoding KATP channel subunits (Kir6.1, Kir6.2, SUR1 and SUR2) was examined in CA1 pyramidal cells and interneurones. Subunit mRNA combinations that can result in functional KATP channels (Kir6.1 together with SUR1, Kir6.2 together with SUR1 or SUR2) were detected in only 17% of the pyramidal cells. On the other hand, KATP channels may be formed in 75% of the interneurones, mainly by the combination of Kir6.2 with SUR1 (58% of all interneurones). 4. The results of these combined analyses indicate that functional KATP channels are present in principal neurones, interneurones and glial cells of the rat hippocampus, but at highly different densities in the four cell types studied.
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