ArticleThe Journal of cell biology1998
Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 105 citations in OpenAlex.
- Molecular mechanism of contactin 2 homophilic interaction.Structure (London, England : 1993) · 2024Article
- Case Report: Two NovelFrontiers in genetics · 2022Article
- Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening.Development (Cambridge, England) · 2021Article
- Article
- TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation.Cell reports · 2020Article
- Exploring the effects of electrospun fiber surface nanotopography on neurite outgrowth and branching in neuron cultures.PloS one · 2019Article
- Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish.Mechanisms of development · 2018Article
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- Influence of maternal thyroid hormones during gestation on fetal brain development.Neuroscience · 2017Review
- Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders.Frontiers in neuroscience · 2015Review
- Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.Nature neuroscience · 2014Article
- Expanding the Ig superfamily code for laminar specificity in retina: expression and role of contactins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules.The Journal of biological chemistry · 2011Article
- Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro.The European journal of neuroscience · 2010Article
- The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.Neurogenetics · 2010Article
- Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes.The Journal of biological chemistry · 2008Article
- The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.Protein science : a publication of the Protein Society · 2007Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural cell adhesion molecules composed of immunoglobulin and fibronectin type III-like domains have been implicated in cell adhesion, neurite outgrowth, and fasciculation. Axonin-1 and Ng cell adhesion molecule (NgCAM), two molecules with predominantly axonal expression exhibit homophilic interactions across the extracellular space (axonin- 1/axonin-1 and NgCAM/NgCAM) and a heterophilic interaction (axonin-1-NgCAM) that occurs exclusively in the plane of the same membrane (cis-interaction). Using domain deletion mutants we localized the NgCAM homophilic binding in the Ig domains 1-4 whereas heterophilic binding to axonin-1 was localized in the Ig domains 2-4 and the third FnIII domain. The NgCAM-NgCAM interaction could be established simultaneously with the axonin-1-NgCAM interaction. In contrast, the axonin-1-NgCAM interaction excluded axonin-1/axonin-1 binding. These results and the examination of the coclustering of axonin-1 and NgCAM at cell contacts, suggest that intercellular contact is mediated by a symmetric axonin-12/NgCAM2 tetramer, in which homophilic NgCAM binding across the extracellular space occurs simultaneously with a cis-heterophilic interaction of axonin-1 and NgCAM. The enhanced neurite fasciculation after overexpression of NgCAM by adenoviral vectors indicates that NgCAM is the limiting component for the formation of the axonin-12/NgCAM2 complexes and, thus, neurite fasciculation in DRG neurons.
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