ArticleThe Journal of cell biology1998
Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- IRX5 Promoted SREBP1-Mediated de Novo Fatty Acid Synthesis via HMGN4 in Hepatocellular Carcinoma.Journal of cellular and molecular medicine · 2025Article
- Visualizing Protein Localizations in Fixed Cells: Caveats and the Underlying Mechanisms.The journal of physical chemistry. B · 2023Review
- The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization.Scientific reports · 2017Article
- Nuclear compartmentalization of α1-adrenergic receptor signaling in adult cardiac myocytes.Journal of cardiovascular pharmacology · 2015Review
- Evolution of high mobility group nucleosome-binding proteins and its implications for vertebrate chromatin specialization.Molecular biology and evolution · 2015Article
- Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.Pharmacological reviews · 2014Review
- High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.The Journal of biological chemistry · 2013Article
- The HMGN family of chromatin-binding proteins: dynamic modulators of epigenetic processes.Biochimica et biophysica acta · 2012Review
- Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes.Cellular signalling · 2012Article
- HMGA1 down-regulation is crucial for chromatin composition and a gene expression profile permitting myogenic differentiation.BMC cell biology · 2010Article
- Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development.Human molecular genetics · 2010Article
- Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments.Critical reviews in eukaryotic gene expression · 2010Review
- High mobility group proteins and their post-translational modifications.Biochimica et biophysica acta · 2008Review
- Cell cycle-dependent binding of HMGN proteins to chromatin.Molecular biology of the cell · 2008Article
- Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells.Chromosoma · 2008Article
- Arabidopsis chromatin-associated HMGA and HMGB use different nuclear targeting signals and display highly dynamic localization within the nucleus.The Plant cell · 2006Article
- Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes.Molecular biology of the cell · 2003Article
- Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins.Molecular and cellular biology · 2002Article
- Article
- Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.Molecular and cellular biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high mobility group 14/17 (HMG-14/-17) proteins form specific complexes with nucleosome core particles and produce distinct footprints on nucleosomal DNA. Therefore, they could be an integral part of the chromatin fiber. Here we show that during the cell cycle these proteins are transiently dissociated from chromatin. They colocalize with the nuclear DNA in interphase and prophase but not in metaphase and anaphase. They relocate into the nucleus and colocalize again with the DNA in late telophase, concomitantly with the appearance of the nuclear envelope. Thus, these nucleosomal binding proteins are not always associated with chromatin. Using reconstituted nuclei and permeabilized cells, we demonstrate that these two small proteins, with a molecular mass <10 kD, are actively imported into the nucleus. We identify the major elements involved in the nuclear import of these chromosomal proteins: HMG-14/-17 proteins contain an intrinsic bipartite nuclear localization signal, and their entry into the nucleus through nuclear pores requires energy and the participation of importin alpha. These findings suggest that the cell cycle-related association of HMG-14/-17 with chromatin is dependent on, and perhaps regulated by, nuclear import processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.