ArticleJournal of bacteriology1998
The aadA gene of plasmid R100 confers resistance to spectinomycin and streptomycin in Myxococcus xanthus.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Physicochemical and Biological Insights Into the Molecular Interactions Between Extracellular DNA and Exopolysaccharides inFrontiers in microbiology · 2022Article
- Distribution and Antibiotic Resistance Profiles ofGeoHealth · 2021Article
- The sigma factor σMolecular microbiology · 2018Article
- aadA confers streptomycin resistance in Borrelia burgdorferi.Journal of bacteriology · 2003Article
- Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production.Journal of industrial microbiology & biotechnology · 2003Article
- Site-specific recombination of temperate Myxococcus xanthus phage Mx8: genetic elements required for integration.Journal of bacteriology · 1999Article
- Site-specific recombination of temperate Myxococcus xanthus phage Mx8: regulation of integrase activity by reversible, covalent modification.Journal of bacteriology · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Plasmids with the aadA gene from plasmid R100, which confers resistance to the aminoglycosides spectinomycin and streptomycin in Escherchia coli, can be introduced into wild-type Myxococcus xanthus, strain DK1622, by electroporation. Recombinant M. xanthus strains with integrated plasmids carrying the aadA gene acquire resistance to high levels of these antibiotics. Selection for aadA in M. xanthus can be carried out independently of, or simultaneously with, selection for resistance to kanamycin. The kinds and frequencies of recombination events observed between integrative plasmids with aadA and the M. xanthus chromosome are similar to those observed after the transformation of yeast. Cleavage of integrative plasmid DNA at a site adjacent to a region of homology between the plasmid and the M. xanthus genome favors the targeted disruption of M. xanthus genes by allele replacement.
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Registered trials
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