ArticleJournal of clinical laboratory analysis1998
Reference distributions for immunoglobulins A, G, and M: a comparison of a large cohort to the world's literature.
Article in Journal of clinical laboratory analysis, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Reference distributions for apolipoproteins AI and B and B/AI ratios: comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2006Pooled it
- Reference distributions for complement proteins C3 and C4: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2004Pooled it
- Reference distributions for serum iron and transferrin saturation: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2002Pooled it
- Reference distributions for the positive acute phase proteins, alpha1-acid glycoprotein (orosomucoid), alpha1-antitrypsin, and haptoglobin: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2000Pooled it
- Reference distributions for the negative acute-phase proteins, albumin, transferrin, and transthyretin: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 1999Pooled it
- A Tool to Eliminate IgM Immunoassay Interference.The AAPS journal · 2025Article
- Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations.Arthritis research & therapy · 2023Article
- Spinal fluid IgG antibodies from patients with demyelinating diseases bind multiple sclerosis-associated bacteria.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Article
- CovR Regulates Streptococcus mutans Susceptibility To Complement Immunity and Survival in Blood.Infection and immunity · 2016Article
- Serum biomarker gMS-Classifier2: predicting conversion to clinically definite multiple sclerosis.PloS one · 2013Article
- Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children.Iranian journal of public health · 2012Article
- Altered immunoglobulin profiles in children with Tourette syndrome.Brain, behavior, and immunity · 2011Article
- Validating pathophysiological models of aging using clinical electronic medical records.Journal of biomedical informatics · 2010Article
- Differential gender effects of a reduced-calorie diet on systemic inflammatory and immune parameters in nonhuman primates.Journal of periodontal research · 2008Article
- Reference distributions for alpha2-macroglobulin: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2004Review
- Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort.Journal of clinical laboratory analysis · 1999Article
- Reference distributions for immunoglobulins A, G, and M: a practical, simple, and clinically relevant approach in a large cohort.Journal of clinical laboratory analysis · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical interpretation of immunoglobulin measurements requires accurate and precise assays and widely accepted reference preparations, as well as reliable age- and gender-specific reference ranges. This last requirement, the topic of numerous publications, has not been addressed adequately. By a combination of computerized and hand searching of the literature from 1961 to 1997, we identified 109 publications presenting IgA, IgG, and/or IgM reference data in healthy individuals. After eliminating studies that lacked appropriate clinical, statistical, or reference material information, data from the 17 acceptable studies were converted to a common reference material, CRM 470/RPPHS. When median levels from our recently published large cohort study are superimposed on these published medians, they fall within the ranges of reported medians. The widths of published 95 percentile reference ranges (where each individual's health was verified) were also found to agree closely with the reference range widths found in our data (where inclusion was based on the reported diagnosis). The current combined study of narrowly applied reference ranges validates our recently published age- and gender-specific reference data for immunoglobulinsA, G, and M. Those new data can now be considered as a source of reliable reference ranges to be used by laboratories when interpreting immunoglobulin measurements.
Indexed as
Identifiers
9850189PMC6807938W1964327261What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.