ArticleThe Pediatric infectious disease journal1998
Management of neonatal candidiasis. Neonatal Candidiasis Study Group.
Article in The Pediatric infectious disease journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Congenital systemic candidiasis: a comprehensive literature review and meta-analysis of 44 cases.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologiePooled it
- Population pharmacokinetics of amphotericin B lipid complex in neonates.Antimicrobial agents and chemotherapy · 2005Trial
- A State of the Art Review on the Recalcitrant Candidiasis as a Clue of Inborn Errors of Immunity in Newborns.Journal of immunology research · 2026Review
- Sixty years of Amphotericin B: An Overview of the Main Antifungal Agent Used to Treat Invasive Fungal Infections.Infectious diseases and therapy · 2021Review
- Epidemiology of Invasive Fungal Infections at Two Tertiary Care Neonatal Intensive Care Units Over a 12-Year Period (2000-2011).Global pediatric health · 2017Article
- Old and new: appropriate dosing for neonatal antifungal drugs in the nursery.Early human development · 2013Review
- Antifungal therapy and outcomes in infants with invasive Candida infections.The Pediatric infectious disease journal · 2012Article
- Congenital cutaneous candidiasis: a rare and unpredictable disease.Indian journal of dermatology · 2011Article
- Preterm neonates with candidal brain microabscesses: a case series.Journal of perinatology : official journal of the California Perinatal Association · 2009Article
- Review
- Invasive fungal infection in very low birthweight infants: national prospective surveillance study.Archives of disease in childhood. Fetal and neonatal edition · 2006Article
- Survey of neonatal candidiasis in Greece.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2005Article
- Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents.Antimicrobial agents and chemotherapy · 2005Article
- Neonatal candidiasis: analysis of epidemiology, drug susceptibility, and molecular typing of causative isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2004Article
- Low yield of ancillary diagnostic studies in neonates infected with Candida.Journal of perinatology : official journal of the California Perinatal Association · 2004Article
- Antifungals in systemic neonatal candidiasis.Drugs · 2004Review
- High-dose liposomal amphotericin B in the therapy of systemic candidiasis in neonates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2003Article
- A very low birth weight infant with Candida nephritis with fungus balls. Full recovery after pyelotomy and antifungal combination therapy.European journal of pediatrics · 2003Article
- Trends in antifungal susceptibility of Candida spp. isolated from pediatric and adult patients with bloodstream infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000.Journal of clinical microbiology · 2002Article
- Commonly used antibacterial and antifungal agents for hospitalised paediatric patients: implications for therapy with an emphasis on clinical pharmacokinetics.Paediatric drugs · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo identify areas of consensus and controversy in the management of neonatal candidiasis.
methodsA questionnaire was distributed to US-based members of the Pediatric Infectious Diseases Society and a sampling of US neonatologists.
resultsThree hundred eighty evaluable questionnaires were returned (42% of those mailed). Ninety-five percent of respondents have cared for an infant with systemic candidiasis in the past 2 years. Fluconazole and liposomal amphotericin are used to some extent by 90 and 69% of respondents, respectively. A single blood culture positive for Candida led to a recommendation for immediate treatment by 99%; amphotericin B was the preferred therapy for candidemia (88%). More than 80% of respondents would request cerebrospinal fluid, urine and repeat blood cultures and ophthalmologic examination in the evaluation of candidemia. If a cerebrospinal fluid culture is positive, 25% would use amphotericin B alone whereas 62% would add flucytosine. For candiduria Society members chose fluconazole therapy more often than did neonatologists, 23% vs. 3.4% (P<0.001). There was no consensus concerning duration of therapy, use of an amphotericin B test dose or management of a central catheter in place during candidemia.
conclusionsSystemic candidiasis in neonates is a frequently encountered clinical problem. There is agreement that prompt therapy with amphotericin B is required if a blood culture is positive for Candida and that such infants require additional evaluations. Other antifungals (fluconazole, liposomal amphotericin B) are used to some extent in this population. Many issues in management have no clear consensus and warrant further research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.