ArticleAnnals of the rheumatic diseases1998
Evidence for genetic anticipation in nodal osteoarthritis.
Article in Annals of the rheumatic diseases, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 25 citations in OpenAlex.
- Possible anticipation associated with a novel splice site mutation in episodic ataxia type 2.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Revisiting the pathogenesis of podagra: why does gout target the foot?Journal of foot and ankle research · 2011Article
- Satellog: a database for the identification and prioritization of satellite repeats in disease association studies.BMC bioinformatics · 2005Article
- Erosive osteoarthritis: presentation, clinical pearls, and therapy.Current rheumatology reports · 2001Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvidence was sought for genetic anticipation (disease occurring at an earlier age in subsequent generations, with increasing severity) in nodal osteoarthritis (NOA).
methodsAge at symptom onset and disease severity was compared within 30 parent/offspring pairs with NOA. Correlation between the offspring age of disease onset and the parental age at conception was also assessed.
resultsThe age at onset of nodal symptoms was earlier in the offspring (43 years (95% confidence intervals (CI) 38 to 47) v 61 (CI 58 to 65); mean difference 18 years (CI 13 to 22): p < 0.001) as was larger joint symptom onset (48 years (CI 41 to 55) v 67 (CI 61 to 73); mean difference 20 years (CI 13 to 27): p < 0.01). A negative correlation existed between age of offspring symptom onset and parental age at conception. Fifteen (50%) offspring had similar or more extensive disease than their parents.
conclusionsThese results suggest genetic anticipation occurs in NOA and if confirmed a search for trinucleotide repeats is warranted.
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Registered trials
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