ArticleRNA (New York, N.Y.)1998
Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP.
Article in RNA (New York, N.Y.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Connecting genotype and phenotype in minor spliceosome diseases.RNA (New York, N.Y.) · 2025Review
- Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome ofCurrent research in food science · 2022Article
- Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA.PLoS genetics · 2017Article
- Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assembly.Molecular and cellular biology · 2005Article
- Both U2 snRNA and U12 snRNA are required for accurate splicing of exon 5 of the rat calcitonin/CGRP gene.RNA (New York, N.Y.) · 2004Article
- Determinants of plant U12-dependent intron splicing efficiency.The Plant cell · 2004Article
- Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP.Molecular and cellular biology · 2004Article
- Branchpoint selection in the splicing of U12-dependent introns in vitro.RNA (New York, N.Y.) · 2002Article
- Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers.RNA (New York, N.Y.) · 2001Article
- Role of the 3' splice site in U12-dependent intron splicing.Molecular and cellular biology · 2001Article
- Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.RNA (New York, N.Y.) · 2001Article
- Analysis of canonical and non-canonical splice sites in mammalian genomes.Nucleic acids research · 2000Article
- AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.Molecular and cellular biology · 1999Review
- Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions.Genes & development · 1999Article
- The significant other: splicing by the minor spliceosome.Wiley interdisciplinary reviews. RNAReview
- Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression.Journal of biomedical scienceReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A rare class of introns in higher eukaryotes is processed by the recently discovered AT-AC spliceosome. AT-AC introns are processed inefficiently in vitro, but the reaction is stimulated by exon-definition interactions involving binding of U1 snRNP to the 5' splice site of the downstream conventional intron. We report that purine-rich exonic splicing enhancers also strongly stimulate sodium channel AT-AC splicing. Intact U2, U4, or U6 snRNAs are not required for enhancer function or for exon definition. Enhancer function is independent of U1 snRNP, showing that splicing stimulation by a downstream 5' splice site and by an exonic enhancer differ mechanistically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.