ArticleRNA (New York, N.Y.)1998
Separable roles in vivo for the two RNA binding domains of Drosophila A1-hnRNP homolog.
Article in RNA (New York, N.Y.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Conservation of gene architecture and domains amidst sequence divergence in theJournal of genetics · 2020Article
- The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.Chromosoma · 2016Article
- Structural basis of nucleic acid binding by Nicotiana tabacum glycine-rich RNA-binding protein: implications for its RNA chaperone function.Nucleic acids research · 2014Article
- HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition.Nucleic acids research · 2013Article
- The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster.Journal of biosciences · 2012Article
- Nuclear export of single native mRNA molecules observed by light sheet fluorescence microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications.PloS one · 2012Article
- Protein synthesis rates in Drosophila associate with levels of the hsr-omega nuclear transcript.Cell stress & chaperones · 2009Article
- Genome-wide analysis of alternative pre-mRNA splicing and RNA-binding specificities of the Drosophila hnRNP A/B family members.Molecular cell · 2009Article
- Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A.Journal of virology · 2004Article
- Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization.The EMBO journal · 1999Article
- Specification of the somatic musculature in Drosophila.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We analyzed the roles of the three domains of a Drosophila hnRNP A1 homolog by expression of wild-type and mutant versions of HRB87F/hrp36 in Drosophila melanogaster. HRB87F/hrp36 is one of two Drosophila proteins that is most similar to mammalian A1 hnRNP, and like A1, consists of two copies of the RNA-binding domain (RBD) motif followed by a glycine-rich domain (GRD). The role of the domains in nuclear localization and RNA binding to polytene chromosomal sites was determined. RBD-1 and the GRD were largely responsible for both the cellular location of the protein and for the typical chromosomal distribution pattern of the protein at sites of PolII transcription. RBD-1 also provided a role in the exon-skipping activity of the protein that was not provided by RBD-2. On the other hand, RBD-2 and the GRD were responsible for the very limited chromosomal distribution pattern seen upon heat shock, when HRB87F/hrp36 is sequestered at heat-shock puff 93D, which encodes a long nucleus-restricted RNA. Thus, these studies indicate that the two RBDs function independently of each other but in concert with the GRD. In addition, the self-association property of the GRD was strikingly evident in these overexpressed proteins.
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