ArticleThe American journal of pathology1998
Uroplakin gene expression by normal and neoplastic human urothelium.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 137 citations in OpenAlex.
- The role of UPK1B in gastric cancer: multi-omics analysis and experimental validation.Discover oncology · 2025Article
- Mimicking Urinary Tract Infections Caused by UropathogenicMicroorganisms · 2024Article
- Detection of Bacteria in Bladder Mucosa of Adult Females.The Journal of urology · 2023Article
- Article
- Generation of Urothelial Cells from Mouse-Induced Pluripotent Stem Cells.International journal of stem cells · 2022Article
- The Golgi complex: An organelle that determines urothelial cell biology in health and disease.Histochemistry and cell biology · 2022Review
- The urothelium: a multi-faceted barrier against a harsh environment.Mucosal immunology · 2022Review
- Comprehensive transcriptome profiling of urothelial cells following TNFα stimulation in anFrontiers in immunology · 2022Article
- Tetraspanins as Potential Modulators of Glutamatergic Synaptic Function.Frontiers in molecular neuroscience · 2021Review
- Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells.International journal of molecular sciences · 2019Article
- Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence.Molecular biology of the cell · 2018Article
- Uroplakin traffic through the Golgi apparatus induces its fragmentation: new insights from novel in vitro models.Scientific reports · 2017Article
- Heterarchy of transcription factors driving basal and luminal cell phenotypes in human urothelium.Cell death and differentiation · 2017Article
- Conditional Expression of the Androgen Receptor Increases Susceptibility of Bladder Cancer in Mice.PloS one · 2016Article
- Downregulation of UPK1A suppresses proliferation and enhances apoptosis of bladder transitional cell carcinoma cells.Medical oncology (Northwood, London, England) · 2015Article
- Glycosylation of uroplakins. Implications for bladder physiopathology.Glycoconjugate journal · 2014Review
- A novel bidirectional positive-feedback loop between Wnt-β-catenin and EGFR-ERK plays a role in context-specific modulation of epithelial tissue regeneration.Journal of cell science · 2014Article
- Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients.PloS one · 2014Article
- Membrane microdomain-associated uroplakin IIIa contributes to Src-dependent mechanisms of anti-apoptotic proliferation in human bladder carcinoma cells.Biology open · 2012Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
cDNA sequences for human uroplakins UPIa, UPIb, UPII, and UPIII were cloned and used to investigate uroplakin transcription by normal and neoplastic urothelial cells. Normal urothelium expressed mRNA for all four uroplakins, although UPIII could be detected only by ribonuclease protection assay. By in situ hybridization, UPIa and UPII were confined to superficial cells and UPIb was also expressed by intermediate cells. Cultured normal human urothelial cells showed a proliferative basal/intermediate cell phenotype and constitutive expression of UPIb only. Uroplakin expression by transitional cell carcinoma cell lines was related to their differentiated phenotype in vitro. RT4 cells expressed all uroplakins, VM-CUB-3 expressed three uroplakins, RT112 and HT1376 cells expressed only UPIb in high abundance, and COLO232, KK47, and EJ cells had no detectable expression. These results correlated with patterns of uroplakin expression in tumors. UPIa and UPII were detected superficially only in well differentiated transitional cell carcinoma papillae. UPIb was positive in seven of nine and overexpressed in five of nine noninvasive transitional cell carcinomas and was also present in four of eight invasive transitional cell carcinomas. Lymph node metastases retained the same pattern of UPIb expression as the primary tumor. Unlike the three differentiation-regulated uroplakins, UPIb may have an alternative role in urothelial cell/tissue processes.
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