ArticleThe American journal of pathology1998
Collagen deposition in a non-fibrotic lung granuloma model after nitric oxide inhibition.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
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- Inflammatory Gene Expression Upon TGF-β1-Induced p38 Activation in Primary Dupuytren's Disease Fibroblasts.Frontiers in molecular biosciences · 2015Article
- Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice.Respiratory research · 2014Article
- Alveolar macrophage depletion increases the severity of acute inflammation following nonlethal unilateral lung contusion in mice.The journal of trauma and acute care surgery · 2014Article
- Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway.The Journal of experimental medicine · 2011Article
- Reprogrammed fibrocytes induce a mixed Th1/Th2 cytokine response of naïve CD4(+) T cells.Molecular and cellular biochemistry · 2011Article
- Nitric oxide in asthma physiopathology.ISRN allergy · 2011Article
- Nitric oxide participation in granulomatous response induced by Paracoccidioides brasiliensis infection in mice.Medical microbiology and immunology · 2009Article
- Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.American journal of respiratory cell and molecular biology · 2009Article
- OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung.European journal of immunology · 2008Article
- Inducible nitric oxide synthase inhibition influenced granuloma formation with suppressed collagen expression in myositis caused by Toxocara canis in mice.Parasitology research · 2008Article
- Effects of nitric oxide synthase inhibitor omega-nitro-L-arginine methyl ester, on silica-induced inflammatory reaction and apoptosis.Particle and fibre toxicology · 2006Article
- Regulation of granuloma fibrosis by nitric oxide during Mycobacterium avium experimental infection.International journal of experimental pathology · 2006Article
- Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy.Journal of immunology (Baltimore, Md. : 1950) · 2006Review
- Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis.The American journal of pathology · 2005Article
- Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice.The American journal of pathology · 2004Article
- Fibrotic disease and the T(H)1/T(H)2 paradigm.Nature reviews. Immunology · 2004Review
- Blockade of CCR2 ameliorates progressive fibrosis in kidney.The American journal of pathology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies support the concept that pulmonary granulomatous inflammation directed by interferon (IFN)-gamma, interleukin (IL)-12, and nitric oxide usually resolves in the absence of fibrosis. To determine whether nitric oxide participates in modulating the fibrotic response during the development of pulmonary granulomas in response to purified protein derivative (PPD), mice presensitized to PPD received daily intraperitoneal injections of N(G)-nitro-D-arginine-methyl ester (D-NAME), N(G)-nitro-L-arginine-methyl ester (L-NAME), or aminoguanidine after delivery of PPD-coated beads to the lungs. Eight days later, morphometric analysis of lung granulomas revealed that L-NAME-treated mice when challenged with PPD in vitro for 36 hours had the largest pulmonary granulomas and the greatest collagen deposition among the treated groups. In addition, equivalent numbers of dispersed lung cells from L-NAME- and aminoguanidine-treated mice produced significantly higher levels of IL-4, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1alpha and significantly lower levels of eotaxin compared with D-NAME-treated mice. Cultures of dispersed lung cells from L-NAME-treated mice also produced significantly more IL-10 and less IL-12 compared with similar numbers of dispersed lung cells from D-NAME-treated mice. Cultures of isolated lung fibroblasts from L-NAME-treated mice expressed higher levels of C-C chemokine receptor 2 (CCR2) and CCR3 mRNA and contained less MCP-1 and eotaxin protein than a similar number of fibroblasts from D-NAME-treated mice. Thus, nitric oxide appears to regulate the deposition of extracellular matrix in lung granulomas through the modulation of the cytokine and chemokine profile of these lesions. Alterations in the cytokine, chemokine, and procollagen profile of this lesion may be a direct effect of nitric oxide on the pulmonary fibroblast and provide an important signal for regulating fibroblast activity during the evolution of chronic lung disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.