ArticleThe American journal of pathology1998
Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 202 citations in OpenAlex.
- Chronic and acute arsenic exposure enhance EGFR expression via distinct molecular mechanisms.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- Arsenic Stimulates Myoblast Mitochondrial Epidermal Growth Factor Receptor to Impair Myogenesis.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes.G3 (Bethesda, Md.) · 2019Article
- Integration of microRNAome, proteomics and metabolomics to analyze arsenic-induced malignant cell transformation.Oncotarget · 2017Article
- Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes.Oncogenesis · 2017Article
- Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer.Molecules (Basel, Switzerland) · 2017Article
- Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides.Journal of inorganic biochemistry · 2016Article
- The effect of arsenic on some antioxidant enzyme activities and lipid peroxidation in various tissues of mirror carp (Cyprinus carpio carpio).Environmental science and pollution research international · 2015Article
- Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells.Biochemical and biophysical research communications · 2015Article
- Co-exposure of arsenic and cadmium through drinking water and tobacco smoking: risk assessment on kidney dysfunction.Environmental science and pollution research international · 2015Article
- p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure.Biochimica et biophysica acta · 2013Article
- Reduction of arsenite-enhanced ultraviolet radiation-induced DNA damage by supplemental zinc.Toxicology and applied pharmacology · 2013Article
- Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Arsenic exposure and toxicology: a historical perspective.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response.Toxicology and applied pharmacology · 2011Article
- Aberrant immune responses in arsenical skin cancers.The Kaohsiung journal of medical sciences · 2011Review
- Concentration-dependent cellular responses of arsenic in keratinocytes.The Kaohsiung journal of medical sciences · 2011Review
- Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs.The Journal of biological chemistry · 2011Article
- Cancer in experimental animals exposed to arsenic and arsenic compounds.Critical reviews in toxicology · 2010Review
- Review
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although numerous epidemiological studies have shown that inorganic arsenicals cause skin cancers and hyperkeratoses in humans, there are currently no established mechanisms for their action or animal models. Previous studies in our laboratory using primary human keratinocyte cultures demonstrated that micromolar concentrations of inorganic arsenite increased cell proliferation via the production of keratinocyte-derived growth factors. As recent reports demonstrate that overexpression of keratinocyte-derived growth factors, such as transforming growth factor (TGF)-alpha, promote the formation of skin tumors, we hypothesized that similar events may be responsible for those associated with arsenic skin diseases. Thus, the influence of arsenic in humans with arsenic skin disease and on mouse skin tumor development in transgenic mice was studied. After low-dose application of tetradecanoyl phorbol acetate (TPA), a marked increase in the number of skin papillomas occurred in Tg.AC mice, which carry the v-Ha-ras oncogene, that received arsenic in the drinking water as compared with control drinking water, whereas no papillomas developed in arsenic-treated transgenic mice that did not receive TPA or arsenic/TPA-treated wild-type FVB/N mice. Consistent with earlier in vitro findings, increases in granulocyte/macrophage colony-stimulating factor (GM-CSF) and TGF-alpha mRNA transcripts were found in the epidermis at clinically normal sites within 10 weeks after arsenic treatment. Immunohistochemical staining localized TGF-alpha overexpression to the hair follicles. Injection of neutralizing antibodies to GM-CSF after TPA application reduced the number of papillomas in Tg.AC mice. Analysis of gene expression in samples of skin lesions obtained from humans chronically exposed to arsenic via their drinking water also showed similar alterations in growth factor expression. Although confirmation will be required in nontransgenic mice, these results suggest that arsenic enhances development of skin neoplasias via the chronic stimulation of keratinocyte-derived growth factors and may be a rare example of a chemical carcinogen that acts as a co-promoter.
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