ArticleThe American journal of pathology1998
Expression of cellular prion protein in activated hepatic stellate cells.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Re-evaluation of the relationship between PrPc expression and patient prognosis in primary esophageal squamous cell carcinoma and primary hepatocellular carcinoma.Scientific reports · 2024Article
- Cellular Prion Protein Is Closely Associated with Early Recurrence and Poor Survival in Patients with Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Prion protein protects mice from lethal infection with influenza A viruses.PLoS pathogens · 2018Article
- Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication.Virologica Sinica · 2017Article
- Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis.Frontiers in pharmacology · 2016Review
- Systems level analysis and identification of pathways and networks associated with liver fibrosis.PloS one · 2014Article
- SCG10 expression on activation of hepatic stellate cells promotes cell motility through interference with microtubules.The American journal of pathology · 2010Article
- Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.Physiological reviews · 2008Review
- Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats.Gut · 2007Article
- Article
- Hepatic stellate cells: Three-dimensional structure, localization, heterogeneity and development.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2006Review
- Lhx2-/- mice develop liver fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers.Virchows Archiv : an international journal of pathology · 2003Article
- Prion diseases: contribution of high-resolution immunomorphology.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suppression subtractive hybridization was used to clone genes associated with the activation of hepatic stellate cells and 13 genes were found to be dominantly expressed in activated stellate cells. Among them, one was identical to the 421-837th base pairs of cDNA sequence reported for rat prion-related protein (PrP). In cultured stellate cells, PrP mRNA expression increased in a time-dependent manner in parallel with smooth muscle (SM) alpha-actin mRNA expression. In situ hybridization demonstrated that PrP mRNA was localized in and around the fibrous septa of carbon tetrachloride (CCl4)-treated liver. Cellular PrP (PrPc) was produced by culture-activated stellate cells, and immunohistochemically detected in the fibrous septa of CCl4-damaged liver and sinusoidal linings of common bile duct-ligated liver, consistent with the localization of SM alpha-actin. Immunoelectron microscopy revealed that PrPc resided on the plasma membrane of stellate cells. These results indicate that PrP expression is closely related to stellate cell activation associated with fibrogenic stimuli.
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