ArticleClinical and experimental immunology1998
Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 173 citations in OpenAlex.
- Albendazole treatment of HIV-1 and helminth co-infection: a randomized, double-blind, placebo-controlled trial.AIDS (London, England) · 2008Trial
- Impact ofTropical medicine and infectious disease · 2025Article
- Immunological and Haematological Relevance of Helminths andBiomedicines · 2024Article
- HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.BMC immunology · 2023Article
- COVID-19 morbidity in lower versus higher income populations underscores the need to restore lost biodiversity of eukaryotic symbionts.iScience · 2023Review
- iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats.PLoS neglected tropical diseases · 2022Article
- Profiles of CD4Medical microbiology and immunology · 2022Article
- Infectious diseases among Ethiopian immigrants in Israel: a descriptive literature review.Pathogens and global health · 2021Review
- Highlighting the Relevance of CD8Frontiers in immunology · 2021Review
- Chronic Immune Activation and CD4Frontiers in immunology · 2021Review
- Impact of Endemic Infections on HIV Susceptibility in Sub-Saharan Africa.Tropical diseases, travel medicine and vaccines · 2019Review
- Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes.The American journal of tropical medicine and hygiene · 2017Review
- Effects of Helminth Eradication on the Immune System.Pathogens & immunity · 2017Review
- Immune function in Amazonian horticulturalists.Annals of human biology · 2016Article
- Helminth infection during pregnancy: insights from evolutionary ecology.International journal of women's health · 2016Review
- Asymptomatic Helminth Infection in Active Tuberculosis Is Associated with Increased Regulatory and Th-2 Responses and a Lower Sputum Smear Positivity.PLoS neglected tropical diseases · 2015Article
- Severe impairment of regulatory T-cells and Th1-lymphocyte polarization in patients with Gaucher disease.JIMD reports · 2015Article
- Profiling B and T cell immune responses to co-infection of Mycobacterium tuberculosis and hookworm in humans.Infectious diseases of poverty · 2015Article
- Schistosoma haematobium infection and CD4+ T-cell levels: a cross-sectional study of young South African women.PloS one · 2015Article
- Co-infection with Schistosoma mansoni and Human Immunodeficiency Virus-1 (HIV-1) among residents of fishing villages of north-western Tanzania.Parasites & vectors · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously reported the presence of marked immune dysregulation with a dominant Th2 profile, in a population of Ethiopian immigrants (ETH) in Israel heavily infected with helminths. In order to characterize better this immune dysregulation we studied by flow cytometry the expression of several activation markers on peripheral T cell populations, and lymphocyte apoptosis, in blood samples obtained from 63 'new' ETH (recently arrived), 18 'old' ETH (> 5 years since immigration) and 34 non-Ethiopian Israelis. The main findings in the 'new' ETH group in comparison with the non-Ethiopian controls were: (i) decreased CD4 and increased CD8 lymphocyte counts; (ii) elevated levels of activated T cells (CD3, CD4 and CD8) expressing HLA-DR; (iii) decreased levels of 'naive' CD4+ cells (CD45RA+), with increased levels of 'memory' CD4+ cells (CD45RO+); (iv) decreased numbers of CD28+ CD8+ lymphocytes; (v) marked increase in lymphocyte apoptosis. These T cell alterations and activation profile remained unchanged in 10 'new' ETH in whom the helminth infections persisted for 6-11 months. In contrast, in 18 'old' ETH, without helminth infections, the T cell activation profile was within the normal range. These findings suggest that chronic helminth infections may have a profound effect on the immune system of the host that disappears after eradication of these infections and adjustment to the new environment. It should therefore be taken into consideration for every immunomodulation therapy and especially in vaccine design and trials, in regions endemic for helminth infections.
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