ArticleClinical and experimental immunology1998
Mapping of topoisomerase II alpha epitopes recognized by autoantibodies in idiopathic pulmonary fibrosis.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses.American journal of respiratory and critical care medicine · 2013Article
- Determinants of initiation and progression of idiopathic pulmonary fibrosis.Respirology (Carlton, Vic.) · 2009Review
- Private specificities can dominate the humoral response to self-antigens in patients with cryptogenic fibrosing alveolitis.Respiratory research · 2001Article
- A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis.Immunology · 2000Article
- Anti-topoisomerase II alpha autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35.Clinical and experimental immunology · 2000Article
- Analysis of the autoimmune epitopes on human testicular NASP using recombinant and synthetic peptides.Clinical and experimental immunology · 2000Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoantibodies against DNA topoisomerase II alpha have been identified in the sera of patients with idiopathic pulmonary fibrosis (IPF). To map topoisomerase II autoepitopes, we tested by ELISA and immunoblotting the IPF anti-topoisomerase II-positive sera against a series of recombinant proteins which covered the full length of topoisomerase II alpha. Specific patterns of reactivity were observed, indicating the existence of multiple epitopes on topoisomerase II, either highly complex or conformational/discontiguous or conformational/contiguous ones. The latter resided in amino acid residues 854-1147 and 1370-1447. A detailed analysis of these regions was undertaken, but we were not able to pinpoint a sequential peptide-sized epitope, or any significant homology with foreign pathogens. Further, we observed a significant correlation between the progression from a contiguous to a quaternary/tertiary structure-dependent autoepitope and the disease duration but not with the disease severity. Therefore, this result supports the hypothesis that anti-topoisomerase II autoreactivity evolves following an antigen-driven process.
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