ArticleProceedings of the National Academy of Sciences of the United States of America1998
Social transmission of reproductive behavior increases frequency of inherited disorders in a young-expanding population.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Comparing ARG Inference Methods Under Transmission of Reproductive Success: Tree Imbalance Matters.Genome biology and evolution · 2026Article
- Article
- Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases.Nature ecology & evolution · 2021Article
- Differences in local population history at the finest level: the case of the Estonian population.European journal of human genetics : EJHG · 2020Article
- Relaxed Selection During a Recent Human Expansion.Genetics · 2018Article
- Older fathers' children have lower evolutionary fitness across four centuries and in four populations.Proceedings. Biological sciences · 2017Article
- Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations.European journal of human genetics : EJHG · 2015Article
- Efficiently tracking selection in a multiparental population: the case of earliness in wheat.Genetics · 2015Article
- High Frequency Haplotypes are Expected Events, not Historical Figures.F1000Research · 2015Article
- Sociocultural behavior, sex-biased admixture, and effective population sizes in Central African Pygmies and non-Pygmies.Molecular biology and evolution · 2013Article
- Cross-national patterns of intergenerational continuities in childbearing in developed countries.Biodemography and social biology · 2013Article
- Genome-wide association study identifies candidate genes for male fertility traits in humans.American journal of human genetics · 2012Article
- Colloquium papers: Heritability of reproductive fitness traits in a human population.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Experimental estimation of mutation rates in a wheat population with a gene genealogy approach.Genetics · 2008Article
- Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory.PloS one · 2007Article
- Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness.American journal of human genetics · 2007Article
- Strong linkage disequilibrium near the selected Yr17 resistance gene in a wheat experimental population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2007Article
- Matrilineal fertility inheritance detected in hunter-gatherer populations using the imbalance of gene genealogies.PLoS genetics · 2006Article
- Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Global patterns in human mitochondrial DNA and Y-chromosome variation caused by spatial instability of the local cultural processes.PLoS genetics · 2006Article
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2 authors.
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Abstract
The observation of high frequencies of certain inherited disorders in the population of Saguenay-Lac Saint Jean can be explained in terms of the variance and the correlation of effective family size (EFS) from one generation to the next. We have shown this effect by using the branching process approach with real demographic data. When variance of EFS is included in the model, despite its profound effect on mutant allele frequency, any mutant introduced in the population never reaches the known carrier frequencies (between 0.035 and 0.05). It is only when the EFS correlation between generations is introduced into the model that we can explain the rise of the mutant alleles. This correlation is described by a c parameter that reflects the dependency of children's EFS on their parents' EFS. The c parameter can be considered to reflect social transmission of demographic behavior. We show that such social transmission dramatically reduces the effective population size. This could explain particular distributions in allele frequencies and unusually high frequency of certain inherited disorders in some human populations.
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