ArticleProceedings of the National Academy of Sciences of the United States of America1998
Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 111 citations in OpenAlex.
- Review
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- The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis.Frontiers in immunology · 2024Article
- Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 inInternational journal of molecular sciences · 2023Article
- Molecular basis for GIGYF-TNRC6 complex assembly.RNA (New York, N.Y.) · 2023Article
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- The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii.Nature communications · 2022Article
- Interaction between DLC-1 and SAO-1 facilitates CED-4 translocation during apoptosis in the Caenorhabditis elegans germline.Cell death discovery · 2022Article
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- Emerging roles of spliceosome in cancer and immunity.Protein & cell · 2022Review
- Creativity comes from interactions: modules of protein interactions in plants.The FEBS journal · 2022Review
- CD2 Immunobiology.Frontiers in immunology · 2020Review
- Validation of systems biology derived molecular markers of renal donor organ status associated with long term allograft function.Scientific reports · 2018Article
- The GYF domain protein PSIG1 dampens the induction of cell death during plant-pathogen interactions.PLoS genetics · 2017Article
- Article
- TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.PloS one · 2011Article
- Proline-rich sequence recognition: I. Marking GYF and WW domain assembly sites in early spliceosomal complexes.Molecular & cellular proteomics : MCP · 2009Article
- Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.The Journal of biological chemistry · 2009Article
- A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
An intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2, was identified. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17-aa motif (GPY[orF]xxxxM[orV]xxWxxx GYF), also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over-expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor. Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.