ArticleProceedings of the National Academy of Sciences of the United States of America1998
A model system to study genomic imprinting of human genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Expression and trafficking of placental microRNAs at the feto-maternal interface.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism.Journal of neuropathology and experimental neurology · 2012Article
- Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15.Genome research · 2010Article
- Immunologic and neurodevelopmental susceptibilities of autism.Neurotoxicology · 2008Review
- DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency.American journal of human genetics · 2007Article
- 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders.Human molecular genetics · 2007Article
- Alternative mechanisms associated with silencing of CDKN1C in Beckwith-Wiedemann syndrome.Journal of medical genetics · 2005Article
- Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome.Journal of medical genetics · 2003Article
- Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.American journal of human genetics · 2003Article
- Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.The Journal of cell biology · 2002Article
- Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.Molecular psychiatry · 2002Article
- Conflicting reports of imprinting status of human GRB10 in developing brain: how reliable are somatic cell hybrids for predicting allelic origin of expression?American journal of human genetics · 2001Article
- Molecular characterisation of four cases of intrachromosomal triplication of chromosome 15q11-q14.Journal of medical genetics · 2001Article
- Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Mechanisms of genomic imprinting.American journal of human genetics · 2000Review
- Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.American journal of human genetics · 2000Article
- Genome-wide scan for body composition in pigs reveals important role of imprinting.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Identification of novel imprinted transcripts in the Prader-Willi syndrome and Angelman syndrome deletion region: further evidence for regional imprinting control.American journal of human genetics · 2000Article
- Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human.Genome research · 2000Article
- Chromosome breakage in the Prader-Willi and Angelman syndromes involves recombination between large, transcribed repeats at proximal and distal breakpoints.American journal of human genetics · 1999Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Somatic-cell hybrids have been shown to maintain the correct epigenetic chromatin states to study developmental globin gene expression as well as gene expression on the active and inactive X chromosomes. This suggests the potential use of somatic-cell hybrids containing either a maternal or a paternal human chromosome as a model system to study known imprinted genes and to identify as-yet-unknown imprinted genes. Testing gene expression by using reverse transcription followed by PCR, we show that functional imprints are maintained at four previously characterized 15q11-q13 loci in hybrids containing a single human chromosome 15 and at two chromosome 11p15 loci in hybrids containing a single chromosome 11. In contrast, three gamma-aminobutyric acid type A receptor subunit genes in 15q12-q13 are nonimprinted. Furthermore, we have found that differential DNA methylation imprints at the SNRPN promoter and at a CpG island in 11p15 are also maintained in somatic-cell hybrids. Somatic-cell hybrids therefore are a valid and powerful system for studying known imprinted genes as well as for rapidly identifying new imprinted genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.