ArticleProceedings of the National Academy of Sciences of the United States of America1998
PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 126 citations in OpenAlex.
- Article
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- The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif.Cellular and molecular life sciences : CMLS · 2020Article
- Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.Acta neuropathologica communications · 2019Article
- Protein interacting with Amyloid Precursor Protein tail-1 (PAT1) is involved in early endocytosis.Cellular and molecular life sciences : CMLS · 2019Article
- C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.Molecular cell · 2018Article
- Exploring the cross talk between ER stress and inflammation in age-related macular degeneration.PloS one · 2017Article
- APP Receptor? To Be or Not To Be.Trends in pharmacological sciences · 2016Review
- Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways.Biology open · 2015Article
- PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons.BMC neuroscience · 2015Article
- Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.Human molecular genetics · 2013Article
- Analysis of AQP4 trafficking vesicle dynamics using a high-content approach.Biophysical journal · 2013Article
- Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production.Human molecular genetics · 2012Article
- Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.Molecular biology of the cell · 2012Article
- Proteolytic processing of Alzheimer's β-amyloid precursor protein.Journal of neurochemistry · 2012Review
- Dynamic distribution of nuclear coactivator 4 during mitosis: association with mitotic apparatus and midbodies.PloS one · 2011Article
- Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System.International journal of Alzheimer's disease · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In epithelial cells, sorting of membrane proteins to the basolateral surface depends on the presence of a basolateral sorting signal (BaSS) in their cytoplasmic domain. Amyloid precursor protein (APP), a basolateral protein implicated in the pathogenesis of Alzheimer's disease, contains a tyrosine-based BaSS, and mutation of the tyrosine residue results in nonpolarized transport of APP. Here we report identification of a protein, termed PAT1 (protein interacting with APP tail 1), that interacts with the APP-BaSS but binds poorly when the critical tyrosine is mutated and does not bind the tyrosine-based endocytic signal of APP. PAT1 shows homology to kinesin light chain, which is a component of the plus-end directed microtubule-based motor involved in transporting membrane proteins to the basolateral surface. PAT1, a cytoplasmic protein, associates with membranes, cofractionates with APP-containing vesicles, and binds microtubules in a nucleotide-sensitive manner. Cotransfection of PAT1 with a reporter protein shows that PAT1 is functionally linked with intracellular transport of APP. We propose that PAT1 is involved in the translocation of APP along microtubules toward the cell surface.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.