ArticleProceedings of the National Academy of Sciences of the United States of America1998
The antibody catalysis route to the total synthesis of epothilones.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Expression and characterization of an enantioselective antigen-binding fragment directed against α-amino acids.Protein expression and purification · 2013Article
- Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics.Angewandte Chemie (International ed. in English) · 2010Article
- Direct observation of an enamine intermediate in amine catalysis.Journal of the American Chemical Society · 2009Article
- Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Multiple event activation of a generic prodrug trigger by antibody catalysis.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Bringing biological solutions to chemical problems.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An efficient monoclonal aldolase antibody that proceeds by an enamine mechanism was generated by reactive immunization. Here, this catalyst has been used in the total synthesis of epothilones A (1) and C (3). The starting materials for the synthesis of these molecules have been obtained by using antibody-catalyzed aldol and retro-aldol reactions. These precursors were then converted to epothilones A (1) and C (3) to complete the total synthesis.
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