ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Contractile activity of circular smooth muscle in rats one year after small bowel transplantation: differing adaptive response of the jejunum and ileum to denervation.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of extrinsic denervation on innervation with VIP and substance P in circular muscle of rat jejunum.Neurogastroenterology and motility · 2008Article
- Effect of chronic, extrinsic denervation on functional NANC innervation with vasoactive intestinal polypeptide and substance P in longitudinal muscle of rat jejunum.Neurogastroenterology and motility · 2008Article
- Long-term effects of extrinsic denervation on VIP and substance P innervation in circular muscle of rat jejunum.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Significance of changes of gastrointestinal peptides in blood and ileum of experimental spleen deficiency rats.World journal of gastroenterology · 2003Article
- Functional changes in nonadrenergic, noncholinergic inhibitory neurons in ileal circular smooth muscle after small bowel transplantation in rats.Digestive diseases and sciences · 1998Article
- Adrenergic denervation hypersensitivity in ileal circular smooth muscle after small bowel transplantation in rats.Digestive diseases and sciences · 1997Article
- Neuronal adrenergic and muscular cholinergic contractile hypersensitivity in canine jejunum after extrinsic denervation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Nitric oxide pathways in circular muscle of the rat jejunum before and after small bowel transplantation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Small bowel transplantation induces adrenergic hypersensitivity in ileal longitudinal smooth muscle in rats.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The aim of the present study was to determine the long-term effects of isogeneic small bowel transplantation (SBT) on jejunal and ileal circular smooth muscle contractile activity in the rat. Transmural strips of circular muscle were prepared from proximal jejunum and distal ileum of 1-year-old control rats and rats 1 year after SBT (SBT-1Y) to measure isometric force. Spontaneous contractile activity and the dose-responses to bethanechol and norepinephrine were studied. Electrical field stimulation (EFS) at varying frequencies (1 to 20 Hz) was evaluated under adrenergic and cholinergic blockade to investigate inhibitory nerves. Spontaneous activity both in the jejunum and ileum in SBT-1Y rats was not different compared to control rats. Sensitivity to bethanechol did not differ between control and SBT-1Y rats in the jejunum or ileum. Sensitivity to norepinephrine, however, was significantly increased after SBT in the ileum but not in the jejunum. During EFS, inhibition was seen at low frequencies, and contractions were induced at high frequencies in all groups. The degree of inhibition did not differ between control and SBT-1Y rats in the jejunum; however, it tended to be increased in the ileum after SBT. The long-term adaptive response of smooth muscle to the extrinsic denervation accompanying SBT differs between the jejunum and the ileum.
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