ArticleProceedings. Biological sciences1998
Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class.
Article in Proceedings. Biological sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.Scientific reports · 2019Article
- Biphasic Effect of Buspirone on the H-Reflex in Acute Spinal Decerebrated Mice.Frontiers in cellular neuroscience · 2019Article
- Intense Activity of the Raphe Spinal Pathway Depresses Motor Activity via a Serotonin Dependent Mechanism.Frontiers in neural circuits · 2017Article
- Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.Frontiers in neural circuits · 2016Review
- Nanomolar oxytocin synergizes with weak electrical afferent stimulation to activate the locomotor CpG of the rat spinal cord in vitro.PloS one · 2014Article
- Multiple monoaminergic modulation of posturo-locomotor network activity in the newborn rat spinal cord.Frontiers in neural circuits · 2014Article
- Microelectrode arrays in combination with in vitro models of spinal cord injury as tools to investigate pathological changes in network activity: facts and promises.Frontiers in neuroengineering · 2013Article
- 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization.The Journal of biological chemistry · 2012Article
- Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse.The Journal of physiology · 2010Article
- Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice.Journal of neurophysiology · 2009Article
- Locomotor-activated neurons of the cat. I. Serotonergic innervation and co-localization of 5-HT7, 5-HT2A, and 5-HT1A receptors in the thoraco-lumbar spinal cord.Journal of neurophysiology · 2009Article
- Serotonergic modulation of locomotion in zebrafish: endogenous release and synaptic mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Opposing aminergic modulation of distinct spinal locomotor circuits and their functional coupling during amphibian metamorphosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Brainstem modulation of locomotion in the neonatal mouse spinal cord.The Journal of physiology · 2008Article
- Dopaminergic modulation of spinal neuronal excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Ontogenic changes of the spinal GABAergic cell population are controlled by the serotonin (5-HT) system: implication of 5-HT1 receptor family.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.British journal of pharmacology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurotransmitter serotonin (5-HT) induces rhythmic motor patterns (fictive locomotion) of the neonatal rat spinal cord in vitro; this is a useful experimental model to study the generation of a motor programme at exclusively spinal level. Nevertheless, 5-HT slows down the fictive locomotion typically elicited by activation of NMDA glutamate receptors, suggesting a complex action of this monoamine. By means of electrophysiological recordings from multiple ventral roots we demonstrated that the decrease caused by 5-HT in NMDA-induced periodicity was dose-dependent, enhanced after pharmacological blocking of 5-HT2 excitatory receptors, and imitated by pharmacological agonists of the 5-HT1 receptor family. Selective blockers of the 5-HT1A or 5-HT1B/D receptor classes, either alone or in combination, largely (but not completely) attenuated this inhibitory action of 5-HT. It is concluded that the principal inhibitory action of 5-HT on the spinal locomotor network was mediated by certain subtypes of the 5-HT1 receptor class, which tends to oppose the 5-HT2 receptor-mediated excitation of the same network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.