ArticleThe Journal of experimental medicine1998
Vav regulates peptide-specific apoptosis in thymocytes.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 98 citations in OpenAlex.
- Review
- Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Novel PKCθ from Benchtop to Clinic.Journal of immunology research · 2015Review
- Article
- Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses.PloS one · 2011Article
- The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells.Acta pharmacologica Sinica · 2011Article
- Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis.European journal of immunology · 2010Article
- Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression.The Journal of biological chemistry · 2010Article
- Rho family GTPases and their regulators in lymphocytes.Nature reviews. Immunology · 2009Review
- Article
- PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.Oncogene · 2005Article
- Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.The Journal of experimental medicine · 2003Article
- Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.The Journal of experimental medicine · 2002Article
- The regulation of DNAse activities in subcellular compartments of activated thymocytes.Immunology · 2002Article
- Deficiency of small GTPase Rac2 affects T cell activation.The Journal of experimental medicine · 2001Article
- Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.Molecular and cellular biology · 2001Article
- Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms.The Journal of experimental medicine · 2001Article
- The calcium-independent protein kinase C participates in an early process of CD3/CD28-mediated induction of thymocyte apoptosis.Immunology · 2000Article
- Regulatory and signaling properties of the Vav family.Molecular and cellular biology · 2000Review
- Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription.Oncogene · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protooncogene Vav functions as a GDP/GTP exchange factor (GEF) for Rho-like small GTPases involved in cytoskeletal reorganization and cytokine production in T cells. Gene-targeted mice lacking Vav have a severe defect in positive and negative selection of T cell antigen receptor transgenic thymocytes in vivo, and vav-/- thymocytes are completely resistant to peptide-specific and anti-CD3/anti-CD28-mediated apoptosis. Vav acts upstream of mitochondrial pore opening and caspase activation. Biochemically, Vav regulates peptide-specific Ca2+ mobilization and actin polymerization. Peptide-specific cell death was blocked both by cytochalasin D inhibition of actin polymerization and by inhibition of protein kinase C (PKC). Activation of PKC with phorbol ester restored peptide-specific apoptosis in vav-/- thymocytes. Vav was found to bind constitutively to PKC-theta in thymocytes. Our results indicate that peptide-triggered thymocyte apoptosis is mediated via Vav activation, changes in the actin cytoskeleton, and subsequent activation of a PKC isoform.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.