ArticleAmerican journal of human genetics1998
Trading genes along the silk road: mtDNA sequences and the origin of central Asian populations.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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86 citing papers in PubMed, 316 citations in OpenAlex.
- West Eurasian mtDNA lineages in India: an insight into the spread of the Dravidian language and the origins of the caste system.Human genetics · 2015Trial
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- Elucidating the genomic basis of rare pediatric neurological diseases in Central Asia and Transcaucasia.Nature genetics · 2024Article
- Ancestral Origins and Admixture History of Kazakhs.Molecular biology and evolution · 2024Article
- The Genetic Echo of the Tarim Mummies in Modern Central Asians.Molecular biology and evolution · 2022Article
- Dual origins of the Northwest Chinese Kyrgyz: the admixture of Bronze age Siberian and Medieval Niru'un Mongolian Y chromosomes.Journal of human genetics · 2022Article
- Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia.PloS one · 2022Article
- Surveillance Metrics of SARS-CoV-2 Transmission in Central Asia: Longitudinal Trend Analysis.Journal of medical Internet research · 2021Article
- Mitochondrial DNA Footprints from Western Eurasia in Modern Mongolia.Frontiers in genetics · 2021Article
- Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population.Bosnian journal of basic medical sciences · 2020Article
- Decoding a highly mixed Kazakh genome.Human genetics · 2020Article
- Genetic diversity and population structure of the Sapsaree, a native Korean dog breed.BMC genetics · 2019Article
- Spirometry in Central Asian Lowlanders and Highlanders, a Population Based Study.Frontiers in medicine · 2019Article
- Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population.Journal of molecular neuroscience : MN · 2018Article
- Mitochondrial genomes uncover the maternal history of the Pamir populations.European journal of human genetics : EJHG · 2018Article
- Genetic risk between theHereditas · 2018Article
- Maternal genetic features of the Iron Age Tagar population from Southern Siberia (1st millennium BC).PloS one · 2018Article
- Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population.Clinical interventions in aging · 2018Article
- Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group.Oncotarget · 2017Article
- Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.BMC medical genetics · 2017Article
26 more citing papers are in PubMed but not listed here.
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12 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central Asia is a vast region at the crossroads of different habitats, cultures, and trade routes. Little is known about the genetics and the history of the population of this region. We present the analysis of mtDNA control-region sequences in samples of the Kazakh, the Uighurs, the lowland Kirghiz, and the highland Kirghiz, which we have used to address both the population history of the region and the possible selective pressures that high altitude has on mtDNA genes. Central Asian mtDNA sequences present features intermediate between European and eastern Asian sequences, in several parameters-such as the frequencies of certain nucleotides, the levels of nucleotide diversity, mean pairwise differences, and genetic distances. Several hypotheses could explain the intermediate position of central Asia between Europe and eastern Asia, but the most plausible would involve extensive levels of admixture between Europeans and eastern Asians in central Asia, possibly enhanced during the Silk Road trade and clearly after the eastern and western Eurasian human groups had diverged. Lowland and highland Kirghiz mtDNA sequences are very similar, and the analysis of molecular variance has revealed that the fraction of mitochondrial genetic variance due to altitude is not significantly different from zero. Thus, it seems unlikely that altitude has exerted a major selective pressure on mitochondrial genes in central Asian populations.
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