ArticleThe Journal of clinical investigation1998
KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.The Journal of experimental medicine · 2021Article
- ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling.Oncogene · 2020Article
- KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer.International journal of oncology · 2018Article
- The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/β-catenin signalling.Cell death & disease · 2018Article
- MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity.Archives of biochemistry and biophysics · 2014Article
- Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks.BMC molecular biology · 2014Article
- Article
- Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.The Journal of biological chemistry · 2013Article
- Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway.Journal of cellular and molecular medicine · 2012Article
- Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases.The Journal of biological chemistry · 2012Article
- Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology.The Journal of biological chemistry · 2012Article
- Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE.Molecular and cellular biochemistry · 2011Article
- A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth.The Biochemical journal · 2011Article
- MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression.PloS one · 2011Article
- The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus.Journal of virology · 2007Article
- Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation.FEBS letters · 2005Article
- Article
- An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation.The EMBO journal · 2003Article
- KRAB-containing zinc-finger repressor proteins.Genome biology · 2003Review
- Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter.The Biochemical journal · 2002Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The study of zinc finger proteins has revealed their potential to act as oncogenes or tumor suppressors. Here we report the molecular, biochemical, and functional characterization of KS1 (KRAB/zinc finger suppressor protein 1), a novel, ubiquitously expressed zinc finger gene initially isolated from a rat pancreas library. KS1 contains 10 C2H2 zinc fingers, a KRAB-A/B motif, and an ID sequence that has been shown previously to participate in growth factor-regulated gene expression. Northern blot analysis using pancreatic cell lines demonstrates that KS1 mRNA is inducible by serum and epidermal growth factor, suggesting a role for this gene in cell growth regulation. Biochemical analysis reveals that KS1 is a nuclear protein containing two transcriptional repressor domains, R1 and R2. R1 corresponds to the KRAB-A motif, whereas R2 represents a novel sequence. Transformation assays using NIH3T3 cells demonstrate that KS1 suppresses transformation by the potent oncogenes Ha-ras, Galpha12, and Galpha13. Deletion of the R1/ KRAB-A domain does not modify the transformation suppressive activity of KS1, whereas deletion of R2 abolishes this function. Thus, KS1 is a novel growth factor-inducible zinc finger transcriptional repressor protein with the potential to protect against neoplastic transformation induced by several oncogenes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.