ArticleAntimicrobial agents and chemotherapy1998
Possible mechanism by which the carbapenem antibiotic panipenem decreases the concentration of valproic acid in plasma in rats.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 54 citations in OpenAlex.
- Effect of a Declined Plasma Concentration of Valproic Acid Induced by Meropenem on the Antiepileptic Efficacy of Valproic Acid.Journal of clinical laboratory analysis · 2024Article
- Clinical impact of carbapenems in critically ill patients with valproic acid therapy: A propensity-matched analysis.Frontiers in neurology · 2023Article
- Potential roles of gut microbiota and microbial metabolites in chronic inflammatory pain and the mechanisms of therapy drugs.Therapeutic advances in chronic disease · 2022Review
- Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units-A Multicenter Delphi Study.Antibiotics (Basel, Switzerland) · 2021Article
- Enteric reabsorption processes and their impact on drug pharmacokinetics.Scientific reports · 2021Article
- Valproate Interaction With Carbapenems: Review and Recommendations.Hospital pharmacy · 2020Article
- Drug Interactions in Neurocritical Care.Neurocritical care · 2017Review
- Influence of enterohepatic recycling on the time course of brain-to-blood partitioning of valproic acid in rats.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
- Ertapenem-induced reduction in valproate levels: case report and review of the literature.The Canadian journal of hospital pharmacy · 2010Article
- Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient.British journal of clinical pharmacology · 2005Article
- Panipenem/betamipron.Drugs · 2003Review
- Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits.Pharmaceutical research · 2001Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence indicating that the carbapenem antibiotic panipenem decreases plasma concentrations of valproic acid (VPA) in epileptic patients during VPA therapy. The mechanism for panipenem-induced changes in the pharmacokinetics of VPA was investigated in rats with and without bile duct cannulation. The effect of panipenem on the pharmacokinetics of diclofenac, which undergoes extensive enterohepatic recirculation, was also examined. VPA (50 mg/kg of body weight) or diclofenac (10 mg/kg of body weight) was administered intravenously under the steady-state plasma panipenem concentration of 4 microgram/ml, which had been achieved by a constant infusion rate. Panipenem decreased the plasma VPA concentrations in rats without bile duct cannulation but did not change the volume of the initial space and protein binding of VPA. However, panipenem had no effect on the plasma VPA concentrations and the biliary excretion of VPA in rats with bile duct cannulation. The secondary increase in plasma diclofenac concentration observed in the absence of panipenem was diminished in the presence of panipenem. These findings suggest that panipenem decreases plasma VPA concentrations by suppressing its enterohepatic recirculation, probably due to a panipenem-induced decrease in the numbers of enteric bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.