ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Glucagon-like peptide 2 is a potent growth factor for small intestine and colon.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 95 citations in OpenAlex.
- The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice.Annals of transplantation · 2024Article
- Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?Nature reviews. Gastroenterology & hepatology · 2022Review
- Intestinal Adaptation upon Chemotherapy-Induced Intestinal Injury in Mice Depends on GLP-2 Receptor Activation.Biomedicines · 2021Article
- Role of glucagon-like peptides in inflammatory bowel diseases-current knowledge and future perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2019Review
- Neuropods.Cellular and molecular gastroenterology and hepatology · 2019Review
- Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats.Aging and disease · 2018Article
- Glucagon-Like Peptide-2 Improve Intestinal Mucosal Barrier Function in Aged Rats.The journal of nutrition, health & aging · 2018Article
- GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting.Therapeutic advances in gastroenterology · 2018Article
- Safety and Efficacy of Teduglutide (Gattex) in Patients With Crohn's Disease and Need for Parenteral Support Due to Short Bowel Syndrome-associated Intestinal Failure.Journal of clinical gastroenterology · 2017Article
- Enteral supplementation with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion.Journal of diabetes investigation · 2015Article
- Novel insight into the distribution of L-cells in the rat intestinal tract.American journal of translational research · 2013Article
- Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.Endocrinology · 2012Article
- Short bowel patients treated for two years with glucagon-like Peptide 2: effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function.Gastroenterology research and practice · 2009Article
- Glicentin inhibits internalization of enteric bacteria by cultured INT-407 enterocytes.Pediatric surgery international · 2007Article
- Advances in short bowel syndrome: an updated review.Pediatric surgery international · 2005Review
- Teduglutide ([Gly2]GLP-2) protects small intestinal stem cells from radiation damage.Cell proliferation · 2004Article
- Glucagon-like peptide 2 stimulates intestinal epithelial proliferation in vitro.Digestive diseases and sciences · 2002Article
- Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM-43004C.Digestive diseases and sciences · 1999Article
- Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Factors that stimulate gut mucosal proliferation may be beneficial during periods of gut disuse or atrophy. Recently glucagon-like peptide 2 (GLP-2) has been shown to stimulate small bowel growth. The purpose of our study was to compare the trophic effects of GLP-2 with those of neurotensin (NT), a potent gut trophic factor. Mice were randomized to receive either GLP-2, NT, or saline solution (control) for 10 days. The mice were killed on day 11, at which time the jejunum, ileum, and colon were removed, weighed, and DNA and protein content measured. Mice treated with GLP-2 showed a significant increase in the weight of the jejunum, ileum, and colon compared to both control and NT-treated mice. DNA content, a marker of cellular hyperplasia, was significantly increased in the small bowel and colon by treatment with GLP-2 and NT compared to control tissues. Small intestinal protein content, an indicator of cellular hypertrophy, was significantly increased by GLP-2 compared to both NT and control; protein content of the colon was greater in each of the treatment groups compared with control mice. We have demonstrated, for the first time, that GLP-2 stimulates colonic growth. In addition, GLP-2 is a potent trophic factor of normal small intestine with proliferative effects that are equal to or greater than those of NT. Administration of GLP-2 may be useful clinically to enhance small intestinal regeneration and adaptation during periods of disease and in the early phases of the short bowel syndrome.
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