ArticleThe Journal of cell biology1998
In vitro repression of Brca1-associated RING domain gene, Bard1, induces phenotypic changes in mammary epithelial cells.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 96 citations in OpenAlex.
- GermlineCancers · 2025Article
- Review
- BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms.Oncogene · 2023Article
- BARD1 mystery: tumor suppressors are cancer susceptibility genes.BMC cancer · 2022Review
- Breast cancer in the era of integrating "Omics" approaches.Oncogenesis · 2022Review
- Article
- Differential Expression ofGenes · 2021Article
- Article
- Literature Review ofGenes · 2020Review
- Review
- Functional characterization of full-length BARD1 strengthens its role as a tumor suppressor in neuroblastoma.Journal of Cancer · 2020Article
- Dualistic Role of BARD1 in Cancer.Genes · 2017Review
- Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability.Oncotarget · 2017Article
- BARD1 serum autoantibodies for the detection of lung cancer.PloS one · 2017Article
- Article
- BARD1 mediates TGF-β signaling in pulmonary fibrosis.Respiratory research · 2015Article
- Review
- Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome.British journal of cancer · 2012Article
- The BARD1 Cys557Ser variant and risk of familial breast cancer in a South-American population.Molecular biology reports · 2012Article
- A novel role for BRCA1 in regulating breast cancer cell spreading and motility.The Journal of cell biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BRCA1-associated RING domain (BARD1) was identified as a protein interacting with the breast cancer gene product BRCA1. The identification of tumorigenic missense mutations within BRCA1 that impair the formation of BARD1-BRCA1 complexes, and of BARD1 mutations in breast carcinomas, sustain the view that BARD1 is involved in BRCA1-mediated tumor suppression. We have cloned the murine Bard1 gene and determined that its expression in different tissues correlates with the expression profile of Brca1. To investigate the function of Bard1, we have reduced Bard1 gene expression in TAC-2 cells, a murine mammary epithelial cell line that retains morphogenetic properties characteristic of normal breast epithelium. Partial repression of Bard1, achieved by the transfection of TAC-2 cells with plasmids constitutively expressing ribozymes or antisense RNAs, resulted in marked phenotypic changes, consisting of altered cell shape, increased cell size, high frequency of multinucleated cells, and aberrant cell cycle progression. Furthermore, Bard1-repressed cell clones overcame contact inhibition of cell proliferation when grown in monolayer cultures and lost the capacity to form luminal structures in three-dimensional collagen gels. These results demonstrate that Bard1 repression induces complex changes in mammary epithelial cell properties which are suggestive of a premalignant phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.