ArticleGenetics1998
Isochore evolution in mammals: a human-like ancestral structure.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Circular RNA repertoires are associated with evolutionarily young transposable elements.eLife · 2021Article
- Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.Journal of molecular evolution · 2020Article
- Marsupial chromosome DNA content and genome size assessed from flow karyotypes: invariable low autosomal GC content.Royal Society open science · 2018Article
- The bimodal distribution of genic GC content is ancestral to monocot species.Genome biology and evolution · 2014Article
- A comparative study and a phylogenetic exploration of the compositional architectures of mammalian nuclear genomes.PLoS computational biology · 2014Article
- Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.Genome research · 2010Article
- Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation.BMC genomics · 2009Article
- Characteristics of human and mouse orthologous protein-coding nucleotide sequences with large g+c content variations.Current genomics · 2007Article
- Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes.Journal of molecular evolution · 2007Article
- Hotspots of mutation and breakage in dog and human chromosomes.Genome research · 2005Article
- Clustering of genes coding for DNA binding proteins in a region of atypical evolution of the human genome.Journal of molecular evolution · 2004Article
- The decline of isochores in mammals: an assessment of the GC content variation along the mammalian phylogeny.Journal of molecular evolution · 2004Article
- Comparative analysis of amino acid repeats in rodents and humans.Genome research · 2004Article
- Isochores and tissue-specificity.Nucleic acids research · 2003Article
- DNA helix: the importance of being GC-rich.Nucleic acids research · 2003Article
- Article
- Vanishing GC-rich isochores in mammalian genomes.Genetics · 2002Article
- Genes on human chromosome 19 show extreme divergence from the mouse orthologs and a high GC content.Nucleic acids research · 2002Article
- Article
Corrections and comments
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Codon usage in mammals is mainly determined by the spatial arrangement of genomic G + C-content, i.e., the isochore structure. Ancestral G + C-content at third codon positions of 27 nuclear protein-coding genes of eutherian mammals was estimated by maximum-likelihood analysis on the basis of a nonhomogeneous DNA substitution model, accounting for variable base compositions among present-day sequences. Data consistently supported a human-like ancestral pattern, i.e., highly variable G + C-content among genes. The mouse genomic structure-more narrow G + C-content distribution-would be a derived state. The circumstances of isochore evolution are discussed with respect to this result. A possible relationship between G + C-content homogenization in murid genomes and high mutation rate is proposed, consistent with the negative selection hypothesis for isochore maintenance in mammals.
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