ArticleGenetics1998
In vivo chromatin accessibility correlates with gene silencing in Drosophila.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression.The FEBS journal · 2026Review
- Article
- Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase.Nature communications · 2021Article
- Review
- Genomic methods in profiling DNA accessibility and factor localization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Article
- Article
- 2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state.The Journal of biological chemistry · 2019Article
- Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.Genome research · 2018Article
- CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo.eLife · 2018Article
- Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells.Nature communications · 2016Article
- Article
- Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing.Nature structural & molecular biology · 2010Article
- High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model.Epigenetics & chromatin · 2009Article
- Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs.Molecular genetics and genomics : MGG · 2008Article
- Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor.Nucleic acids research · 2003Article
- Telomeric associated sequences of Drosophila recruit polycomb-group proteins in vivo and can induce pairing-sensitive repression.Genetics · 2003Article
- batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor.Molecular and cellular biology · 2003Article
- Article
- Native and recombinant polycomb group complexes establish a selective block to template accessibility to repress transcription in vitro.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene silencing by heterochromatin is a well-known phenomenon that, in Drosophila, is called position effect variegation (PEV). The long-held hypothesis that this gene silencing is associated with an altered chromatin structure received direct support only recently. Another gene-silencing phenomenon in Drosophila, although similar in its phenotype of variegation, has been shown to be associated with euchromatic sequences and is dependent on developmental regulators of the Polycomb group (Pc-G) of gene products. One model proposes that the Pc-G products may cause a local heterochromatinization that maintains a repressed state of transcription of their target genes. Here, we test these models by measuring the accessibility of white or miniwhite sequences, in different contexts, to the Escherichia coli dam DNA methyltransferase in vivo. We present evidence that PEV and Pc-G-mediated repression mechanisms, although based on different protein factors, may indeed involve similar higher-order chromatin structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.