ArticleGenetics1998
A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP.Frontiers in molecular neuroscience · 2017Article
- The cis-regulatory code of Hox function in Drosophila.The EMBO journal · 2012Article
- Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.Molecular and cellular biology · 2012Article
- CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.Development (Cambridge, England) · 2009Article
- Article
- Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence.BMC developmental biology · 2008Article
- A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye.Genetics · 2005Article
- Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A.The Biochemical journal · 2005Article
- CREB binding protein functions during successive stages of eye development in Drosophila.Genetics · 2004Article
- A screen for genes that interact with the Drosophila pair-rule segmentation gene fushi tarazu.Genetics · 2004Article
- A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo.Genetics · 2002Article
- Regulation of hematopoietic stem cell fate.Oncogene · 2002Review
- Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers.Molecular and cellular biology · 2000Article
- Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.Molecular and cellular biology · 2000Article
- RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research · 2000Article
- Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity.The Journal of heredityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We have screened the Drosophila X chromosome for genes whose dosage affects the function of the homeotic gene Deformed. One of these genes, extradenticle, encodes a homeodomain transcription factor that heterodimerizes with Deformed and other homeotic Hox proteins. Mutations in the nejire gene, which encodes a transcriptional adaptor protein belonging to the CBP/p300 family, also interact with Deformed. The other previously characterized gene identified as a Deformed interactor is Notch, which encodes a transmembrane receptor. These three genes underscore the importance of transcriptional regulation and cell-cell signaling in Hox function. Four novel genes were also identified in the screen. One of these, rancor, is required for appropriate embryonic expression of Deformed and another homeotic gene, labial. Both Notch and nejire affect the function of another Hox gene, Ultrabithorax, indicating they may be required for homeotic activity in general.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.