ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology1998
Repeated epidemics caused by extended-spectrum beta-lactamase-producing Serratia marcescens strains.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Molecular Characterization by Whole-Genome Sequencing of Clinical and EnvironmentalDiagnostics (Basel, Switzerland) · 2022Article
- Risk factors for mortality in patients with Serratia marcescens bacteremia.Yonsei medical journal · 2015Article
- Serratia infections: from military experiments to current practice.Clinical microbiology reviews · 2011Review
- Molecular epidemiology of Serratia marcescens in two hospitals in Gdańsk, Poland, over a 5-year period.Journal of clinical microbiology · 2004Article
- Extended epidemic of nosocomial urinary tract infections caused by Serratia marcescens.Journal of clinical microbiology · 2003Article
- Characterization of clinical isolates of Enterobacteriaceae from Italy by the BD Phoenix extended-spectrum beta-lactamase detection method.Journal of clinical microbiology · 2003Article
- Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period.Journal of clinical microbiology · 2002Article
- Characterization of a cytotoxic factor in culture filtrates of Serratia marcescens.Infection and immunity · 2002Article
- Occurrence of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae in Italy: implications for resistance to beta-lactams and other antimicrobial drugs.Antimicrobial agents and chemotherapy · 2002Article
- An outbreak of multiply resistant Serratia marcescens: the importance of persistent carriage.Bone marrow transplantation · 2000Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An outbreak of Serratia marcescens involving 42 patients admitted to the general intensive care unit of the Hospital of Varese, Italy, occurred from March 1994 to August 1995. The causative strains were resistant to oxyimino-cephalosporins and monobactams due to their production of an extended-spectrum beta-lactamase. Another outbreak caused by Serratia marcescens strains had occurred in the same unit a few months earlier, from February to October 1993, with the strains involved producing a novel TEM-derived extended-spectrum beta-lactamase. In order to verify whether there were any relationships between isolates from the two epidemics, the strains and their enzymes were characterized. Biochemical data and gene amplification experiments showed that the isolates of the second outbreak harbored a non-conjugative plasmid of approximately 48 kb, codifying for the production of an SHV-derived extended-spectrum beta-lactamase with pI 8.2. Restriction fragment length polymorphism analysis of total genomic DNA by pulsed-field gel electrophoresis of Serratia marcescens isolates unambiguously identified two different bacterial clones responsible for the two epidemics. Epidemiological and microbiological investigations demonstrated the long persistence of Serratia marcescens strains and their circulation in other hospital wards, thus suggesting their possible role as a long-term reservoir for further epidemic spread.
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