ArticleThe Journal of physiology1999
Regional crypt function in rat large intestine in relation to fluid absorption and growth of the pericryptal sheath.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Synergistic protection of combined probiotic conditioned media against neonatal necrotizing enterocolitis-like intestinal injury.PloS one · 2013Article
- Estrogen-dependent regulation of sodium/hydrogen exchanger-3 (NHE3) expression via estrogen receptor β in proximal colon of pregnant mice.Histochemistry and cell biology · 2012Article
- Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis.The Journal of biological chemistry · 2011Article
- Expression and localization of aquaporin-1 on the apical membrane of enterocytes in the small intestine of bottlenose dolphins.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
- Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Role of vasopressin in rat distal colon function.The Journal of physiology · 2007Article
- The hormonal control of uterine luminal fluid secretion and absorption.The Journal of membrane biology · 2005Article
- Aldosterone reduces crypt colon permeability during low-sodium adaptation.The Journal of membrane biology · 2005Article
- Pericryptal myofibroblast growth in rat descending colon induced by low-sodium diets is mediated by aldosterone and not by angiotensin II.The Journal of membrane biology · 2005Article
- Article
- Phospholipase C and src tyrosine kinases mediate neurotensin-stimulated Cl- secretion in rabbit proximal colon.Digestive diseases and sciences · 2004Article
- Localization of thrombomodulin in pericryptal fibroblasts of the rat duodenum.Histochemistry and cell biology · 2004Article
- I, 2. Physiology and pathophysiology of the gut in relation to viral diarrhea.Perspectives in medical virology · 2003Article
- Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by transforming growth factor beta and angiotensin II.BMC gastroenterology · 2002Article
- Evidence of amiloride-sensitive fluid absorption in rat descending colonic crypts from fluorescence recovery of FITC-labelled dextran after photobleaching.The Journal of physiology · 2001Article
- Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors.BMC physiology · 2001Article
- Article
- Colon water transport in transgenic mice lacking aquaporin-4 water channels.American journal of physiology. Gastrointestinal and liver physiology · 2000Article
- Article
- Aquaporin water channels in gastrointestinal physiology.The Journal of physiology · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Confocal microscopic studies of rat colonic mucosa showed that the pericryptal sheath surrounding distal colonic crypts is an effective barrier both to dextran and NaCl movement, whereas no such structure surrounds the caecal crypts. 2. The distal colonic pericryptal barrier was functionally demonstrated by accumulation of Sodium Green within the pericryptal space. After exposure to benzamil, Sodium Green accumulation was decreased. Fluorescein isocyanate-labelled dextran (FITC dextran; molecular mass 10000 Da) was accumulated in the crypt lumens and pericryptal spaces. Both dextran and Sodium Green accumulation were absent from the pericryptal zone surrounding caecal crypts. 3. Low dietary Na+ intake raised rat plasma aldosterone and stimulated distal pericryptal sheath growth and adhesiveness as shown by increased amounts of F-actin, smooth muscle actin, beta-catenin and E-cadherins in the pericryptal zone. It also raised the capacity of the distal colon to dehydrate against a high luminal hydraulic resistance. This linkage indicates that trophic effects on the colon resulting from a low Na+ diet are not confined solely to effects on transepithelial Na+ transport, but are observed in the pericryptal sheath. 4. A computer model of crypt function confirms that a pericryptal sheath with low permeability to NaCl is an essential component of the crypt dehydrating mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.