ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners1998
Are spouses of patients with hypertension at increased risk of having hypertension? A population-based case-control study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Spousal concordance for hypertension: A meta-analysis of observational studies.Journal of clinical hypertension (Greenwich, Conn.) · 2017Pooled it
- Health behaviour change interventions for couples: A systematic review.British journal of health psychology · 2017Pooled it
- Clustering of hypertension and clustering of diabetes within households across districts of India: A cross-sectional analysis using a nationally representative household survey.PLOS global public health · 2025Article
- Spousal Concordance of Hypertension Among Middle-Aged and Older Heterosexual Couples Around the World: Evidence From Studies of Aging in the United States, England, China, and India.Journal of the American Heart Association · 2023Article
- What causes concordance of hypertension between spouses in India? Identifying a critical knowledge gap from a nationally representative cross-sectional sample of 63,020 couples aged 15 + years.BMC public health · 2023Article
- Spousal Similarities in Cardiovascular Risk Factors in Northern China: A Community-Based Cross-Sectional Study.International journal of public health · 2023Article
- For better and worse? The roles of closeness, marital behavior, and age in spouses' cardiometabolic similarity.Psychoneuroendocrinology · 2020Article
- Spousal metabolic risk factors and incident hypertension: A longitudinal cohort study in Iran.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Marriage and Gut (Microbiome) Feelings: Tracing Novel Dyadic Pathways to Accelerated Aging.Psychosomatic medicine · 2019Article
- Lovesick: How Couples' Relationships Influence Health.Annual review of clinical psychology · 2017Review
- Are spouses' socio-economic classifications interchangeable? Examining the consequences of a commonly used practice in studies on social inequalities in health.International journal of public health · 2015Article
- Hypertension status, treatment, and control among spousal pairs in a middle-aged adult cohort.American journal of epidemiology · 2011Article
- Married couples' risk of same disease: cross sectional study.BMJ (Clinical research ed.) · 2002Article
- The family contribution to health status: a population-level estimate.Annals of family medicineArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies of couples, who tend to share an environment but are genetically dissimilar, can shed light on the contribution of environmental factors to hypertension. There has been renewed interest in these environmental factors following the re-analysis of the INTERSALT study.
aimTo determine whether patients whose spouses have hypertension are at increased risk of hypertension, using a population-based case-control study.
methodThe total study population consisted of all 3923 patients over 30 years old registered with one general practice. Male cases with hypertension were matched to male controls without hypertension. Female cases with hypertension were matched to female controls without hypertension. The variables were: diagnosed hypertension; having a spouse with diagnosed hypertension; age; sex; weight; height; body-mass index; couple status; diabetes; and systolic and diastolic blood pressure readings.
resultsOn multivariate analysis, when age, body-mass index, diabetes, couple status, and having a blood pressure reading were included, men whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted odds ratio (OR) 2.24; 95% CI 1.77-2.72; P = 0.001). Similarly, on multivariate analysis, women whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted OR = 2.23; 95% CI 1.75-2.72; P = 0.001). The risk for both male and female subjects persisted after adjustment for other variables. There was a significant correlation between systolic (r = 0.41; P < 0.0001) and diastolic (r = 0.25; P < 0.0001) blood pressures between spouse pairs.
conclusionThe independent association between having a spouse with hypertension and increased risk of hypertension supports the view that there are significant environmental factors in the aetiology of hypertension. The finding has implications for the screening and treatment of hypertension in primary care.
Indexed as
Identifiers
9830183PMC1313221W2203092014What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.