ArticleJournal of bacteriology1998
A homolog of CcpA mediates catabolite control in Listeria monocytogenes but not carbon source regulation of virulence genes.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Listeria monocytogenes requires phosphotransferase systems to facilitate intracellular growth and virulence.PLoS pathogens · 2025Article
- The Global Regulator CcpA ofFrontiers in microbiology · 2022Article
- CcpA Coordinates Growth/Damage Balance for Streptococcus pyogenes Pathogenesis.Scientific reports · 2018Article
- Listeriolysin O: from bazooka to Swiss army knife.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Transcriptomic Analysis of the Adaptation ofFrontiers in microbiology · 2017Article
- Investigation into the role of catabolite control protein A in the metabolic regulation ofExperimental and therapeutic medicine · 2015Article
- Interaction with enzyme IIBMpo (EIIBMpo) and phosphorylation by phosphorylated EIIBMpo exert antagonistic effects on the transcriptional activator ManR of Listeria monocytogenes.Journal of bacteriology · 2015Article
- Dual role of CcpC protein in regulation of aconitase gene expression in Listeria monocytogenes and Bacillus subtilis.Microbiology (Reading, England) · 2013Article
- Carbon catabolite control is important for Listeria monocytogenes biofilm formation in response to nutrient availability.Current microbiology · 2012Article
- Toward a Systemic Understanding of Listeria monocytogenes Metabolism during Infection.Frontiers in microbiology · 2012Article
- Diversity in transcripts and translational pattern of stress proteins in marine extremophiles.Extremophiles : life under extreme conditions · 2011Review
- Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection.Infection and immunity · 2011Article
- Carbon metabolism of intracellular bacterial pathogens and possible links to virulence.Nature reviews. Microbiology · 2010Review
- Maltose and maltodextrin utilization by Listeria monocytogenes depend on an inducible ABC transporter which is repressed by glucose.PloS one · 2010Article
- Regulation of mannose phosphotransferase system permease and virulence gene expression in Listeria monocytogenes by the EII(t)Man transporter.Applied and environmental microbiology · 2009Article
- Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus.BMC microbiology · 2009Article
- CcpC-dependent regulation of citrate synthase gene expression in Listeria monocytogenes.Journal of bacteriology · 2009Article
- Glycerol metabolism and PrfA activity in Listeria monocytogenes.Journal of bacteriology · 2008Article
- The alternative sigma factor sigma B and the virulence gene regulator PrfA both regulate transcription of Listeria monocytogenes internalins.Applied and environmental microbiology · 2007Article
- Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Readily utilizable sugars down-regulate virulence gene expression in Listeria monocytogenes, which has led to the proposal that this regulation may be an aspect of global catabolite regulation (CR). We recently demonstrated that the metabolic enzyme alpha-glucosidase is under CR in L. monocytogenes. Here, we report the cloning and characterization from L. monocytogenes of an apparent ortholog of ccpA, which encodes an important mediator of CR in several low-G+C-content gram-positive bacteria. L. monocytogenes ccpA (ccpALm) is predicted to encode a 335-amino-acid protein with nearly 65% identity to the gene product of Bacillus subtilis ccpA (ccpABs). Southern blot analysis with a probe derived from ccpALm revealed a single strongly hybridizing band and also a second band of much lower intensity, suggesting that there may be other closely related sequences in the L. monocytogenes chromosome, as is the case in B. subtilis. Disruption of ccpALm resulted in the inability of the mutant to grow on glucose-containing minimal medium or increase its growth rate in the presence of preferred sugars, and it completely eliminated CR of alpha-glucosidase activity in liquid medium. However, alpha-glucosidase activity was only partially relieved from CR on solid medium. These results suggest that ccpA is an important element of carbon source regulation in L. monocytogenes. Nevertheless, utilizable sugars still down-regulate the expression of hly, which encodes the virulence factor hemolysin, in a ccpALm mutant, indicating that CcpA is not involved in carbon source regulation of virulence genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.