ArticleJournal of molecular neuroscience : MN1998
Glial expression of the proenkephalin gene in slice cultures of the subventricular zone.
Article in Journal of molecular neuroscience : MN, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Molecular Insights into the Neurogenic Potential of Alpha-lipoic Acid.Current topics in medicinal chemistry · 2026Article
- Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides.Neurobiology of stress · 2025Review
- Article
- Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide.Neuroscience · 2007Article
- Neuroprotection by endogenous and exogenous PACAP following stroke.Regulatory peptides · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proenkephalin (PEnk) gene is expressed in rats in the neocortical subventricular zone (nSVZ) of the lateral ventricle during the first postnatal week, when precursors of astro- and oligoglial cells of the rat neocortex proliferate in this area. To study the expression of the gene in the glial precursors, slices containing the nSVZ were prepared from the brains of newborn and 7-day-old rats. After 1-5 d of cultivation, numerous cells that expressed PEnk mRNA were found in the nSVZ with in situ hybridization. Some of these cells coexpressed the glial fibrillary acidic protein (GFAP), indicating that they were of astroglial origin. Activation of protein kinase A with 8Br.cAMP strongly enhanced the number of cells that expressed the PEnk gene in slices prepared from the brains of newborn or 7-d-old rats. Also pituitary adenylate cyclase activating polypeptide (PACAP) proved to be effective. After stimulation with 8Br.cAMP or PACAP-38, PEnk mRNA-containing cells were found in the subventricular zone as well as in the adjacent area through which glial cells migrate on their way to the neocortex. It has therefore been concluded that protein kinase A may regulate the expression of the PEnk gene expression in glial precursors in the nSVZ.
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